趋化因子CXCL16和CA153及TSGF在乳腺癌诊断中的应用  

Clinical application of CXCL16 and CA153 and TSGF in the diagnosis of breast cancer

作　　者：张小南[1] 朱跃进[1] 颜永乾 邓洁 ZHANG Xiaonan;ZHU Yuejin;YAN Yongqian;DENG Jie(Department of Clinical Laboratory,Luzhou Maternal and Child Health Hospital/Luzhou Second People′s Hospital,Luzhou,Sichuan 646000,China)

机构地区：[1]泸州市妇幼保健院/泸州市第二人民医院检验科

出　　处：《现代医药卫生》2019年第12期1788-1790,1794,共4页Journal of Modern Medicine & Health

摘　　要：目的探讨趋化因子C-X-C-基元配体16(CXCL16)、乳腺癌相关抗原(CA153)和恶性肿瘤特异生长因子(TSGF)在乳腺癌诊断和治疗监测中的应用。方法采用酶联免疫吸附试验(ELISA)检测2015年1月1日至2017年12月31日收治的50例健康女性体检者(健康对照组)、72例良性乳腺肿瘤患者(良性乳腺疾病组)、94例乳腺癌患者(乳腺癌组)和83例其他肿瘤患者(其他肿瘤组)外周血中CXCL16,酶法检测TSGF,化学发光法检测CA153,并进行对比分析。结果乳腺癌组的3种指标均高于健康对照组和良性乳腺疾病组,乳腺癌组的CA153水平高于其他肿瘤组,差异均有统计学意义(P<0.05)。而乳腺癌组及其他肿瘤组CXCL16、TSGF水平比较,差异均无统计学意义(P>0.05)。在乳腺癌组中,随着临床分期的升高,CXCL16、CA153和TSGF水平递增,Ⅲ+Ⅳ期显著高于Ⅰ+Ⅱ期,有淋巴结转移者显著高于无转移者,差异均有统计学意义(P<0.05)。与手术前比较,乳腺癌组81例患者CXCL16、CA153和TSGF水平在手术后显著下降,差异均有统计学意义(P<0.05)。CA153特异性最高,CXCL16灵敏度最高,CXCL16、CA153和TSGF联合检测可提高对乳腺癌灵敏度、阴性预测值和阳性预测值。结论CXCL16、CA153和TSGF对乳腺癌术后随访有一定的意义,CXCL16、CA153和TSGF联合检测有助于提高对乳腺癌的早期诊断率。Objective To discuss clinical application of CXCL16 and CA153 and TSGF in the diagnosis and therapy of breast cancer. Methods CXCL16 in 50 health women(healthy control group),72 patients with benign breast disease(benign breast disease group) and 94 patients with malign breast disease(breast cancer group) and 83 patients with other malignant tumors (other tumor group)of the hospital from January 1,2015 to December 31,2017 were detected by ELSIA.TSGF were detected by enzyme method.CA153 was detected by chemical luminous method.The results were analyzed comparatively. Results CXCL16 and CA153 and TSGF in breast cancer group were higher than those in healthy controls group and benign breast disease group,CA153 in breast cancer group were higher than those in other tumor group,the differences were statistically significant ( P < 0.05 ).There were no significant differences in CXCL16 and TSGF between breast cancer group and other tumor group ( P >0.05).In breast cancer group,with the increase of clinical stages,and CXCL16 and CA153 and TSGF in the stage of Ⅲ+Ⅳ were higher than those of Ⅰ+Ⅱ,the lymph node metastasis was significantly higher than that in the non metastasis,the differences were statistically significant ( P < 0.05 ).Compared with that before surgery,the levels of CXCL16,CA153,and TSGF in 81 patients in the breast cancer group decreased significantly after surgery,with statistically significant differences ( P <0.05).The specificity of CA153 was highest.The sensitivity of CXCL16 was highest.The sensitivity and negative predictive and positive predictive value were improved by the combined of CA153 and CXCL16 and TSGF. Conclusion CXCL16 and CA153 and TSGF can follow-up the curative effect of breast cancer after operation,the joint detection of CXCL16、CA153 and TSGF is helpful to improve the rate of early diagnosis of breast cancer.

关 键 词：趋化因子 CXC CXCL16 癌胚抗原 CA-15-3抗原 TSGF 乳腺疾病 乳腺肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]