3,3,5,5-四甲基联苯胺的合成研究  

Study on the Synthesis of 3,3 5,5-Tetramethylbenzidine

作　　者：徐鹤 谷少华[2] 邢冰梅 毛龙飞[3] 姜玉钦[3] Xu He;Gu Shaohua;Xing Bingmei;Mao Longfei;Jiang Yuqin(Topfond Pharmaceutical Co.,Ltd.,Zhumadian 463000,China;Xinxiang Central Hospital,Xinxiang 453000,China;Henan Normal University,Xinxiang 453007,China)

机构地区：[1]天方药业有限公司,河南驻马店463000 [2]新乡市中心医院,河南新乡451191 [3]河南师范大学化学化工学院,河南新乡453007

出　　处：《山东化工》2019年第11期18-19,23,共3页Shandong Chemical Industry

摘　　要：3,3,5,5-四甲基联苯胺是一种重要的色原试剂。本文以2,6-二甲基苯胺为原料,经过活化、氧化偶联和提纯,得到纯品3,3,5,5-四甲基联苯胺,总收率达到65%。产品经过核磁氢谱和核磁碳谱表征。该路线能有效减少副产物。The important chromogen reagent,3,3 5,5-Tetramethylbenzidine,was synthesized by the reaction of excitation,oxidation coupled and purification,using2,6-dimethylaniline as the starting material. An overall yield of 65% was achieved. The structure was confirmed by1H NMR and13 C NMR. This method can reduce by-product effectively.

关 键 词：3 3 5 5-四甲基联苯胺 2 6-二甲基苯胺 合成 

分 类 号：TQ246.3[化学工程—有机化工]