Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment  

作　　者：Yongjuan Li Jian Hu Xun Liu Yong Liu Shixian Lv Juanjuan Dang Yong Ji Jinlin He Lichen Yin 

机构地区：[1]Institute of Functional Nano and Soft Materials (FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices,Soochow University,Suzhou 215123,China [2]College of Chemistry,Chemical Engineering and Materials Science,Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis,Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application,Soochow University,Suzhou 215123,China [3]Department of Biomedical Engineering,University of Groningen and University Medical Center Groningen,Antonius Deusinglaan 1,9713 AV Groningen, The Netherlands [4]Department of Cardiothoracic Surgery,Wuxi Peoples Hospital Affiliated to Nanjing Medical University,Wuxi 214023,China

出　　处：《Nano Research》2019年第5期999-1008,共10页纳米研究（英文版）

摘　　要：Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemic circulation,and lack of cancer-selective drug release.Herein,a poly(ethylene glycol)(PEG)-polyphosphoester-based,reactive oxygen species (ROS)-responsive,core-cross-linked (CCL) micellar system was developed to encapsulate both chemodrug (doxorubicin,Dox) and photosensitizer (chlorin e6,Ce6).The hydrophobic core of the micelles was cross-linked via a thioketal (TK)-containing linker,which notably enhanced the drug loading and micelle stability.In tumor cells,far-red light irradiation of Ce6 generated ROS to cleave the TK linkers and disrupt the micelle cores.As such,micelles were destabilized and Dox release was promoted,which thereafter imparted synergistic anti-cancer effect with ROS-mediated photodynamic therapy.This study provides an effective approach to realize the precise control over drug loading,formulation stability,and cancer-selective drug release using polymeric micelles,and would render promising utilities for the programmed anti-cancer combination therapy.

关 键 词：core-cross-linked micelles ON-DEMAND drug release photodynamic THERAPY reactive oxygen species (ROS) RESPONSIVENESS SYNERGISTIC an ti-cancer THERAPY 

分 类 号：O4[理学—物理]