Let-7家族启动子区多态性与胃癌的关联研究  

Association between polymorphisms in the promoter region of let-7 family and risk of gastric cancer

作　　者：张麒[1] 艾良[1] ZHANG Qi;AI Liang(Department of Abdominal Surgery,Yunnan Cancer Hospital,Kunming,Yunnan 650118,China)

机构地区：[1]云南省肿瘤医院腹部外科

出　　处：《国际检验医学杂志》2019年第12期1489-1492,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨let-7i启动子区rs10877887和let-7a-1/let-7f-1/let-7d簇启动子区rs13293512多态性与胃癌发生的关系。方法采用TaqMan探针法检测172例胃癌患者和224例健康对照中rs10877887和rs13293512的分布频率,运用χ2检验分析其与胃癌的相关性。结果胃癌患者中rs10877887CC、CT/CC基因型和C等位基因频率明显高于健康对照组(20.9%vs.13.4%,63.4%vs.53.1%,42.2%vs.33.3%),调整优势比(OR)分别为1.98、1.53和1.46(P=0.02、0.04和0.01)。rs13293512位点在胃癌组和健康对照组中的分布差异无统计学意义(P>0.05)。结论let-7i启动子区rs10877887多态性与中国汉族人群胃癌的发病有关。Objective To explore the association of rs10877887 in the promoter of let-7i and rs13293512 in the promoter of let-7a-1/let-7f-1/let-7d cluster with the risk of gastric cancer. Methods The rs10877887 and rs13293512 polymorphisms were genotyped in 172 patients with gastric cancer and 224 healthy controls using a TaqMan assay,and the association between the two polymorphisms and risk of gastric cancer was analyzed using chi-square test. Results The frequencies of rs10877887 CC,CT/CC genotypes and C allele in patients with gastric cancer were significantly higher than those in healthy controls (20.9% vs. 13.4%;63.4% vs. 53.1%;and 42.2% vs. 33.3%),with adjusted odds ratio (OR) of 1.98,1.53,and 1.46,respectively (P= 0.02 ,0.04,0.01).However,no significant difference of the distribution of rs13293512 was observed between patients with gastric cancer and healthy controls (P >0.05). Conclusion The rs10877887 in the promoter of let-7i is associated with the risk of gastric cancer in the Chinese Han population.

关 键 词：微小RNA LET-7 启动子 单核苷酸多态性 胃癌 

分 类 号：R737[医药卫生—肿瘤]