多烯磷脂酰胆碱预防急性早幼粒细胞白血病患者肝损伤的效果观察  

Effect of polyene phosphatidylcholine on prevention of liver injury in patients with acute promyelocytic leukemia

作　　者：张慧琪[1] 黄静 ZHANG Huiqi;HUANG Jing(Department of Hematology, the First People's Hospital of Huzhou City in Zhejiang Province, Huzhou 313000,China)

机构地区：[1]浙江省湖州市第一人民医院血液科

出　　处：《中国现代医生》2019年第15期91-94,共4页China Modern Doctor

基　　金：浙江省湖州市科技计划公益性应用研究项目(2017GYB04)

摘　　要：目的探讨多烯磷脂酰胆碱胶囊预防急性早幼粒细胞白血病患者肝损伤的效果观察。方法按随机数字表法将2016年3月~2018年3月期间我院接诊的74例急性早幼粒细胞白血病患者分为两组,两组患者接受常规化疗,对照组接受甘草酸二铵胶囊治疗,观察组患者接受多烯磷脂酰胆碱胶囊预防治疗。比较两组治疗起效情况、各项肝功能指标、维持治疗阶段不良反应发生情况。结果观察组首次完全缓解时间、PLT开始回升时间、Hb开始回升时间均少于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组ALT、AST、TBIL水平均低于本组治疗前,差异具有统计学意义(P<0.05)。对照组患者ALT、AST、TBIL水平与治疗前相比,差异无统计学意义(P>0.05)。治疗后,观察组ALT、AST、TBIL水平低于对照组,差异具有统计学意义(P<0.05)。观察组末梢神经异常、头痛头昏、肌肉关节疼痛、皮疹等不良反应发生率与对照组相比,差异无统计学意义(P>0.05)。结论对急性早幼粒细胞白血病患者采用多烯磷脂酰胆碱胶囊预防治疗,能够缩短治疗起效时间,保护肝功能,避免肝功能损伤,降低不良反应发生率,安全性较高。Objective To investigate the effect of polyene phosphatidylcholine capsule on preventing liver injury in patients with acute promyelocytic leukemia. Methods According to the random number table method, 74 patients with acute promyelocytic leukemia admitted to our hospital from March 2016 to March 2018 were divided into two groups. The two groups were both given conventional chemotherapy, and the control group was treated with diammonium glycyrrhizinate capsules, while patients in the observation group were given polyene phosphatidylcholine capsules for preventive treatment. The efficacy of treatment, the indicators of liver function, and the adverse reactions in the maintenance treatment phase were compared between the two groups. Results The first complete remission time, the start time of PLT recovery, and the start time of Hb recovery were shorter in the observation group than in the control group, and the differences were statistically significant(P<0.05). The ALT, AST, and TBIL levels in the observation group after treatment were lower than those before treatment, and the differences were statistically significant (P<0.05). There was no significant difference in the levels of ALT, AST and TBIL in the control group before and after treatment(P>0.05). After treatment, the levels of ALT, AST and TBIL in the observation group were lower than those in the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions such as peripheral nerve abnormalities, headache and dizziness, muscle and joint pain, and rash between the observation group and the control group(P>0.05). Conclusion The use of polyene phosphatidylcholine capsules in patients with acute promyelocytic leukemia can shorten the treatment onset time, protect liver function, avoid liver function damage, reduce the incidence of adverse reactions, and have higher safety.

关 键 词：急性早幼粒细胞白血病 多烯磷脂酰胆碱胶囊 肝功能 不良反应 

分 类 号：R733.71[医药卫生—肿瘤]