苹果酸脱氢酶2在肿瘤中的作用机制  

Functional mechanism of malate dehydrogenase 2 in tumors

作　　者：吴颖 付白雪 戴璐 黄俊 滕一镔 李琳琳[2] 章静雯 黄玉红[1] Wu Ying;Fu Baixue;Dai Lu;Huang Jun;Teng Yibin;Li Linlin;Zhang Jingwen;Huang Yuhong(Department of Pathology, Basic Medical College of Dalian Medical University, Dalian 116044, China;Clinical Medical College of Dalian Medical University, Dalian 116044, China)

机构地区：[1]大连医科大学基础医学院病理教研室,116044 [2]大连医科大学临床医学院,116044

出　　处：《国际肿瘤学杂志》2019年第3期178-180,共3页Journal of International Oncology

基　　金：辽宁省教育厅科学研究项目(L2013356);教育部留学回国人员科研启动基金(〔2010〕1561).

摘　　要：苹果酸脱氢酶2(MDH2)在肿瘤中的作用存在双面性,在一些肿瘤中具有促癌作用,而在另一些肿瘤中具有抑制作用。MDH2的功能与能量代谢、肿瘤耐药性及其伪缺氧相互联系。MDH2在肿瘤的发生、发展、侵袭和转移中起重要作用,深入了解MDH2在肿瘤中的作用机制,可为临床提供新的肿瘤干预分子靶点。The role of malate dehydrogenase 2 (MDH2) in tumors is double-sided, it has a cancer-promoting effect in some tumors and an inhibitory effect in other tumors. The function of MDH2 is related to energy metabolism, tumor resistance and its pseudo hypoxia. MDH2 plays an important role in the occurrence, development, invasion and metastasis of tumors. An in-depth understanding of the functional mechanism of MDH2 in tumors can provide new molecular targets for tumor intervention in the clinic.

关 键 词：氧化还原酶类 肿瘤 苹果酸脱氢酶2 

分 类 号：R730.2[医药卫生—肿瘤]