神经酰胺影响α-突触核蛋白聚集作用的研究进展  

Research progress of ceramide in Parkinson’s disease

作　　者：韩燕银 刘承伟[1] HAN Yanyin;LIU Chengwei(Guilin Medical University,Guilin 541004,China)

机构地区：[1]桂林医学院

出　　处：《华夏医学》2019年第1期151-155,共5页Acta Medicinae Sinica

基　　金：国家自然科学基金地区基金资助项目(81760241);广西自然科学基金青年基金资助项目(2017GXNSFBA198019);国家科技支撑计划课题资助项目(2012BAI10B03);广西脑与认知神经科学重点实验室开放课题资助项目(2017-6)

摘　　要：帕金森病(PD)的发生发展与alpha-突触核蛋白(α-syn)的异常聚集息息相关。丝氨酸129位点(S-129)磷酸化的α-syn易聚集形成可溶性的寡聚化α-突触核蛋白(O-α-syn),O-α-syn对神经元具有毒性作用。神经酰胺(Ceramide)是维持细胞膜结构的重要组分,同时作为第二信使,参与细胞分化、增殖、凋亡和衰老等生命活动的调节。近年来发现神经酰胺与蛋白磷酸酶2A,polo样激酶2及葡糖脑苷脂酶的相互作用对α-突触核蛋白寡聚化的形成与否具有重要的作用。笔者将神经酰胺影响α-突触核蛋白聚集的作用进行综述。The pathogenesis of Parkinson’s disease(PD)is closely related to the abnormal accumulation of alpha-synuclein(α-syn). The α-syn phosphorylated at the serine 129 site(S-129)is apt to aggregate to form soluble oligomeric α-synuclein(O-α-syn), which has a toxic effect on neurons. As a key component for maintaining cell membrane structure, ceramide is a second messenger participating in the regulation of life activities such as cell differentiation, proliferation, apoptosis and aging. Recently, it has demonstrated that the interactions of ceramide with protein phosphatase 2 A, polo-like kinase 2 and glucocerebrosidase play an important role in the formation of oligomeric α-synuclein. Hence, this review will summarize the role of ceramide in α-synuclein aggregation.

关 键 词：神经酰胺 帕金森病 Α-突触核蛋白 蛋白磷酸酶2A polo样激酶2 葡糖脑苷脂酶 

分 类 号：R741[医药卫生—神经病学与精神病学]