癫痫患者认知功能障碍的危险因素分析  

Analysis of risk factors for cognitive dysfunction in patients with epilepsy

作　　者：秦晋 罗晓梅 李浩洋[1] 李季萌 魏世丽 张庆[2] QIN Jin;LUO Xiaomei;LI Haoyang;LI Jimeng;WEI Shili;ZHANG Qing(Ningxia Medical University, Yinchuan 750004, China;Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan 750004, China)

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学总医院神经内科,银川750004

出　　处：《癫痫杂志》2019年第3期170-175,共6页Journal of Epilepsy

基　　金：国家自然科学基金(81271443);宁夏颅脑疾病重点实验室开放课题资助(XY201513)

摘　　要：目的分析癫痫患者认知功能障碍的危险因素,为临床防治提供依据。方法收集2018年1月1日—2019年1月31日期间就诊于宁夏医科大学总医院癫痫专科门诊的癫痫患者101例,采用简易精神状态检查(Mini-mental state examination,MMSE)量表评估癫痫患者的认知功能,依据MMSE量表评分,分为认知功能障碍组和认知功能正常组,应用单因素和Logistic回归分析比较两组影响因素的差异。结果①101例癫痫患者中认知功能障碍者27例,认知功能障碍的发生率为26.7%;②单因素分析显示,病程、发作频率、发作形式、抗癫痫药物(AEDs)用药种类及脑电图(EEG)异常率两组差异具有统计学意义(P<0.05);③Logistic回归显示:病程、发作频率及AEDs多药治疗是癫痫患者认知功能障碍的独立危险因素(P<0.05)。结论病程、发作频率及AEDs多药治疗是癫痫患者认知功能障碍的独立危险因素。Objective To analyze the risk factors of cognitive dysfunction in patients with epilepsy, and provide evidence for clinical prevention and treatment. Methods During the period from January 1, 2018 to January 31, 2019,101 patients with epilepsy who were admitted to the epilepsy specialist clinic of the General Hospital of Ningxia Medical University were included in this study. The cognitive function of the patients was evaluated by the Mini-mental State Examination(MMSE) scale and patients were divided into cognitive impairment group and normal cognitive function group according to the MMSE. Single factor and logistic regression analysis were used to find the differences of influencing factors between the two groups. Results ① There were 27 cases of cognitive dysfunction in 101 patients with epilepsy, the incidence of cognitive impairment was 26.7%;② Univariate analysis showed that the course of disease,frequency of seizures, seizure forms, anti-epileptic drugs(AEDs) and abnormal rate of electroencephalogram(EEG)existed significant differences between the two groups(P<0.05).③ Logistic regression showed that course of disease,frequency of seizures and AEDs multidrug therapy were independent risk factors for cognitive dysfunction in patients with epilepsy(P<0.05). Conclusion Course of disease, frequency of seizures and AEDs multidrug therapy are independent risk factors for cognitive dysfunction in patients with epilepsy.

关 键 词：癫痫 认知功能障碍 危险因素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]