FHL2在宫颈癌组织中表达及与临床病理特征及预后的相关性  

Expression of FHL2 in cervical carcinoma and its correlation with clinicopathological features and prognosis

作　　者：张延志[1] 李永丽[1] Zhang Yanzhi;Li Yongli(Department of Gynecology,Binzhou Central Hospital,Binzhou 251700,China)

机构地区：[1]滨州市中心医院妇科,251700

出　　处：《国际医药卫生导报》2019年第12期1934-1936,共3页International Medicine and Health Guidance News

摘　　要：目的 探讨FHL2在宫颈癌组织中表达及与临床病理特征及预后的相关性。方法 选取本院2014年2月至2015年3月间收治的86例宫颈癌患者,子宫肌瘤患者52例,宫颈上皮瘤变患者72例,采用免疫组织化学方法检测FHL2组织表达情况,分析其与临床病理特征及预后的相关性。结果 FHL2在子宫肌瘤、CIN组织、宫颈癌组织的阳性表达率比较,差异有统计学意义(P<0.05);FHL2表达水平与宫颈组织病变程度呈正关系(r=0.536,P<0.001);FHL2阳性表达率与宫颈癌患者的肌层浸润程度、肿瘤大小及患者年龄无关,差异均无统计学意义(均P>0.05);宫颈癌Ⅱ期的患者FHL2阳性表达率100.0%,高于Ⅰ期83.1%,差异有统计学意义(P<0.05);有淋巴结转移的宫颈癌患者FHL2阳性表达率100.0%,明显高于无淋巴结转移的宫颈癌患者73.7%,差异有统计学意义(P<0.05);FHL2在高分化、中分化及低分化的宫颈癌患者中的阳性表达率分别为72.7%、91.8%、100.0%,差异均有统计学意义(P<0.05);随访时间范围为7~48个月,中位随访24个月;因肿瘤复发去世17例,其中1例FHL2阴性表达者死亡,16例FHL2阳性表达者患者,FHL2阴性表达者3年生存率90.0%,高于FHL2阳性表达者78.9%,差异有统计学意义(P<0.05)。结论 FHL2在宫颈癌组织中高表达,与其分化程度及淋巴癌转移情况密切相关,可作为宫颈癌预后评价的相关指标。Objective To investigate the expression of FHL2 in cervical carcinoma and its correlation with clinicopathological features and prognosis.Methods 86 cases of cervical cancer,52 cases of uterine leiomyoma,and 72 cases of cervical epithelioma were selected.The expression of FHL2 was detected by immunohistochemical method.Its correlation with clinicopathological features and prognosis was analyzed.Results The positive expression rates of FHL2 in uterine leiomyoma,CIN,and cervical carcinoma were statisically different(P<0.05).The positive rate of FHL2 positively correlated with the degree of cervical lesions(r=0.536,P<0.001).The positive expression rate of FHL2 was not related to the degree of myometrial invasion,tumor size,and age of patients with cervical cancer(all P>0.05).The positive expression rate of FHL2 in the patients with cervical cancer in stageⅡwas higher than that in stageⅠ(100.00 vs.83.1%,P<0.05).The positive expression rate of FHL2 in cervical cancer with lymph node metastasis was significantly higher than that in cervical cancer without lymph node metastasis(100.0 vs.73.7%,P<0.05).The positive expression rates of FHL2 in highly,moderately and poorly differentiated cervical cancer patients were72.7%,91.8%and 100.0%,respectively(P<0.05).The followed up time was 7 to 48 months,with a median of 24 months.17 patients died of tumor recurrence;one of the 10 patients with negative expression of FHL2 died;and 16 of the 76 patients with positive expression of FHL2 died.The 3-year survival rate of the FHL2 negative expression group was higher than that of the FHL2 positive expression group(90.0%vs.78.9%,P<0.05).Conclusion The high expression of FHL2 in cervical carcinoma is associated with its differentiation process.Degree and lymphatic metastasis are closely related,and can be used as prognostic indicators of cervical cancer.

关 键 词：FHL2 宫颈癌 临床病理特征 相关性 

分 类 号：R737.33[医药卫生—肿瘤]