学龄前男童营养状况与尿促性腺激素及性激素水平的关系研究  

Relationship of Nutritional Status with Urine Gonadotropin and Sex Hormones in Preschool Boys

作　　者：王永 陈春梅 马亚萍 杭飚 杭胤 芮芳 姚敏 秦丽琴 贲泽 聂双 徐庄剑 WANG Yong;CHENChunmei;MA Yaping;HANG Biao;HANG Yin;RUI Fang;YAO Min;QIN Liqin;BEN Ze;NIE Shuang;XU Zhuangjian(Binhu District Mashan Street Community Health Centre,Wuxi 214091,China;Department of Paediatrics,Affiliated Hospital of Jiangnan University/the Fourth People's Hospital of Wuxi,Wuxi 214062,China;Binhu District Hudai Community Health Centre,Wuxi 214161,China)

机构地区：[1]江苏省无锡市滨湖区马山街道社区卫生服务中心,14091 [2]江南大学附属医院,无锡市第四人民医院儿科,江苏省无锡市214062 [3]江苏省无锡市滨湖区胡埭镇社区卫生服务中心,214161

出　　处：《中国全科医学》2019年第20期2416-2421,共6页Chinese General Practice

基　　金：无锡市卫生和计划生育委员会科研项目(ME201508);江苏省妇幼健康科研项目(F201637);无锡市“科教强卫工程”医学重点人才培育对象(ZDRCPY019);无锡市卫生局科研项目(ME201411);无锡市卫生局妇幼保健科研项目(FYKY201404);无锡市医院管理中心科研项目(YGZXM14015)

摘　　要：背景营养状况可能影响儿童体内促性腺激素(Gn)和性激素水平,目前主要是对7岁以上儿童血液中激素的研究,且研究样本量较小。目的观察不同营养状况学龄前男童的尿Gn(UGn)、尿性激素水平,为无创性UGn和尿性激素的流行病学研究和临床应用提供参考依据。方法 2015年5月-2016年12月选取江苏省无锡市马山和胡埭社区学龄前男童(3岁≤年龄<7岁)为研究对象,测量其身高、体质量,计算其年龄别身高Z评分(HAZ)、年龄别体质量Z评分(WAZ)、体质指数(BMI)、年龄别体质指数Z评分(BAZ),并根据HAZ、WAZ、BAZ评分将其各分为6组。留取学龄前男童过夜晨尿,采用免疫化学发光法检测尿黄体生成素(ULH)、尿卵泡刺激素(UFSH)、尿雌三醇(UE3)、尿雌二醇(UE2)、尿睾酮(UT)。采用Kruskal-Wallis H检验进行多组间差异性比较,采用Kruskal-Wallis单因素方差分析进行多组间两两差异性比较,采用Spearman秩相关进行相关性分析。结果符合本研究纳入标准并成功留尿的学龄前男童共871例,ULH、UFSH、UE3、UE2、UT的检出率分别为6.7%(58/871)、99.4%(866/871)、99.7%(868/871)、99.8%(869/871)、98.0%(854/871)。不同HAZ组间UE3比较,差异有统计学意义(P<0.05),其中He、Hf组均高于Hc组,He组高于Hd组(P<0.05);各组UE2比较,差异有统计学意义(P<0.05),其中Hb组高于Ha、Hc、Hd组,He、Hf组高于Hc组(P<0.05);各组UT比较,差异有统计学意义(P<0.05),其中He、Hf组均高于Hc组,He组高于Hd组(P<0.05)。不同WAZ组间UFSH比较,差异有统计学意义(P<0.05),其中Wf组高于Wc、Wd、We组(P<0.05);各组UE3比较,差异有统计学意义(P<0.05),其中Wf组高于Wc、Wd、We组(P<0.05);各组UE2比较,差异有统计学意义(P<0.05),其中Wc组低于Wb组,Wf组高于Wc、Wd、We组(P<0.05);各组UT比较,差异有统计学意义(P<0.05),其中Wf组高于Wc、Wd、We组(P<0.05)。不同BAZ组间UFSH比较,差异有统计学意义(P<0.05),其中Bf组高于Bb、Bc、Bd组(P<0Background Nutritional status may affect gonadotropin(Gn)and sex hormone levels in children.Currently,related studies mainly focus on the effect of nutritional status on the above hormones in blood of children over 7 years old,with relatively small sample sizes.Objective To explore the levels of urine Gn and sex hormones in normal preschool boys with different nutritional status,providing a reference for epidemiological study and clinical application of urine Gn and sex hormones using non-invasive approaches.Methods Preschool boys at least 3 years of age but less than 7 were selected from Mashan Street and Hudai Communities,Jiangsu’s Wuxi from May 2015 to December 2016.Height and weight were measured,and height-for-age Z-score(HAZ),weight-for-age Z-score(WAZ)and BMI-for-age Z-score(BAZ)were calculated.According to HAZ,WAZ and BAZ,they were divided into 6 groups,respectively.The first morning urine samples were collected.The urinary luteinizing hormone(ULH),urinary follicle-stimulating hormone(UFSH),urinary estriol(UE3),urinary estradiol(UE2),and urinary testosterone(UT)were determined by immunochemiluminometric assay.Kruskal-wallis H test was used to compare the differences among HAZ,WAZ and BAZ groups,respectively.Kruskal-wallis one-way ANOVA was conducted to compare the differences between HAZ,WAZ and BAZ groups,respectively.Spearman rank correlation was performed to analyze the correlations of urine Gn and sex hormones with HAZ,height,WAZ,weight,BAZ and BMI.Results A total of 871 boys who met the inclusion criteria with successful urine specimen collection were included.The detection rates of ULH,UFSH,UE3,UE2 and UT were 6.7%(58/871),99.4%(866/871),99.7%(868/871),99.8%(869/871)and98.0%(854/871),respectively.UE3 showed significant differences among HAZ groups(P<0.05),in particular,UE3 in Hc group was much lower than that of He and Hf groups,and UE3 in He group was much higher than that of Hd group(P<0.05).UE2 differed significantly among HAZ groups(P<0.05),to be specific,UE2 in Hb group was much higher than t

关 键 词：营养状况 儿童 学龄前 尿促性腺激素 尿性激素 免疫化学发光法 

分 类 号：R153[医药卫生—营养与食品卫生学]