Mena蛋白与TES蛋白在肿瘤侵袭转移中的作用研究进展  

Advances in the role of Mena and TES proteins in tumor invasion and metastasis

作　　者：齐学袖 QI Xuexiu(School of Medicine and Life Sciences,Jinan University,Jinan 250200,China)

机构地区：[1]济南大学医学与生命科学学院

出　　处：《药学研究》2019年第6期351-354,共4页Journal of Pharmaceutical Research

摘　　要：Mena蛋白是Ena/VASP家族蛋白之一,在细胞伪足的形成和延伸、细胞的运动中起着重要的作用;TES是一种细胞黏附分子,在细胞外抑制肿瘤细胞的迁移和侵袭。近年来研究表明,肿瘤细胞伪足的形成和延伸以及细胞黏附是影响肿瘤细胞迁移和侵袭的主要原因,本文通过探讨Mena蛋白与TES蛋白相互作用对肿瘤细胞伪足和细胞运动能力以及细胞黏附的影响,阐明Mena蛋白与TES蛋白在肿瘤细胞迁移和侵袭过程中的作用及分子机制,为肿瘤转移患者分子靶向治疗提供新的治疗靶点策略和思路。Mena protein is one of the Ena/VASP family proteins,which plays an important role in the formation and extension of cell pseudopods and cell movement.TES is a cell adhesion molecule,which inhibits the migration and invasion of cancer cells in vitro.Recent studies have shown that the formation and extension of pseudopods and cell adhesion are the main factors affecting the migration and invasion of cancer cells.In this paper,the effects of the interaction between Mena and TES proteins on the pseudopods,cell motility and cell adhesion of cancer cells were discussed to elucidate the migration and invasion of Mena and TES in cancer cells.The role and molecular mechanism in the process provide new therapeutic target strategies and ideas for cancer metastasis patients.

关 键 词：Mena蛋白 TES蛋白 相互作用 肿瘤 侵袭 转移 

分 类 号：R73-73R735[医药卫生—肿瘤]