叉头框-C2基因功能的研究进展  

Progress on the function of forkhead box C2

作　　者：黄钰(综述) 吴玉斌(审校)[1,2] Huang Yu;Wu Yubin(Department of Pediatric Nephrology, Rheumatism and Immunology of Shengjing Hospital of China Medical University, Shenyang 110004, China;The Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310051, China)

机构地区：[1]中国医科大学附属盛京医院小儿肾脏风湿免疫科,沈阳110004 [2]浙江大学医学院附属儿童医院,杭州310051

出　　处：《国际儿科学杂志》2019年第5期336-339,共4页International Journal of Pediatrics

基　　金：辽宁省科技厅科学技术计划项目(2013225086).

摘　　要：叉头框-C2(forkhead box C2,FOXC2)是叉头样/翼状螺旋家族的一个转录因子,具有典型的forkhead结构域,在胚胎及产前发育中发挥重要作用。FOXC2在肿瘤细胞增殖及转移、血管生成、淋巴管生成、肾脏疾病及新陈代谢中起着关键的调节作用,但确切的机制尚不明了。因此,对FOXC2的深入研究有助于进一步了解其相关疾病的发生及发展机制。该文就目前对FOXC2基因的认识及其功能的研究进展进行综述。FOXC2, a transcription factor of the forkhead/winged-helix family, possesses a classical forkhead domain, which is required for embryonic and prenatal development.FOXC2 acts as a crucial modulator during tumor cell proliferation, metastasis, angiogenesis, lymphangiogenesis, renal disease and metabolism, but very little is known about the precise underlying mechanisms.Therefore, an in-depth study of FOXC2 is helpful to further understand the pathogenesis and developmental mechanism of FOXC2-related diseases.The purpose of this review is to summarize the current understanding of FOXC2 and its function.

关 键 词：叉头框-C2 上皮-间充质转分化 肿瘤 肾脏 

分 类 号：R394[医药卫生—医学遗传学]