异丙托溴铵联合布地奈德雾化吸入对老年肺癌患者胸腔镜肺叶切除围手术期的影响研究  

Study on effect of ipratropium bromide combined with budesonide aerosol inhalation on perioperative period of thoracoscopic lobectomy in elderly patients with lung cancer

作　　者：高佳 吕洪钦[1] 林燕 GAO Jia;LYU Hong-qin;LIN Yan(Heze Municipal hospital,Heze 274031,China)

机构地区：[1]菏泽市立医院

出　　处：《中国实用医药》2019年第16期1-4,共4页China Practical Medicine

摘　　要：目的研究异丙托溴铵联合布地奈德雾化吸入对老年肺癌患者胸腔镜肺叶切除围手术期的影响。方法 160例接受胸腔镜肺叶切除术的老年肺癌患者,按照随机对照原则分为对照组与研究组,各80例。对照组采用0.9%氯化钠溶液雾化吸入治疗,研究组采用异丙托溴铵联合布地奈德雾化吸入治疗。观察比较两组患者的肺功能指标、血气分析指标、血清白细胞介素-10(IL-10)水平以及并发症发生情况。结果入院时,两组患者第1秒用力呼气容积(FEV1)、每分钟最大通气量(MVV)、用力肺活量(FVC)水平比较,差异无统计学意义(P>0.05)。术前1 d,研究组FEV1(2.13±0.25)L、MVV(98.30±2.70)L、FVC(2.62±0.19)L均高于对照组的(1.98±0.21)、(92.70±1.97)、(2.36±0.28)L,差异均具有统计学意义(P<0.05)。两组患者入院时动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)水平比较,差异无统计学意义(P>0.05)。研究组患者术前1 d及术后7 d的PaO2、PaCO2水平均优于入院时,差异具有统计学意义(P<0.05)。对照组患者术前1 d及术后7 d的PaO2、PaCO2水平与入院时比较,差异无统计学意义(P>0.05)。研究组患者术前1 d及术后7 d的PaO2、PaCO2水平均优于对照组,差异具有统计学意义(P<0.05)。两组入院时、术前1 d、术后7 d的血氧饱和度(SaO2)水平组间与组内比较,差异均无统计学意义(P>0.05)。入院时,两组患者血清IL-10水平比较,差异无统计学意义(P>0.05)。术前1 d,两组患者血清IL-10水平均低于入院时,且研究组患者IL-10水平(52.7±5.3)ng/ml低于对照组的(56.1±6.7)ng/ml,差异具有统计学意义(P<0.05)。研究组患者并发症发生率为11.25%,低于对照组的25.00%,差异具有统计学意义(P<0.05)。结论在老年肺癌患者行胸腔镜肺叶切除围手术期,给予患者异丙托溴铵联合布地奈德雾化吸入治疗,能改善患者的肺功能及血气分析各项指标,降低血清IL-10水平及并发症发生率,效果较Objective To study the effect of ipratropium bromide combined with budesonide aerosol inhalation on perioperative period of thoracoscopic lobectomy in elderly patients with lung cancer. Methods A total of 160 elderly patients with lung cancer undergoing thoracoscopic lobectomy were divided by randomized control principle into control group and research group, with 80 cases in each group. The control group received 0.9% NaCl aerosol inhalation, and the research group received ipratropium bromide combined with budesonide aerosol inhalation. Observation and comparison were made on pulmonary function index, blood gas analysis index, serum interleukin-10(IL-10) level and occurrence of complications between the two groups. Results At admission, both groups had no statistically significant difference in forced expiratory volume in 1 second(FEV1), maximum ventilation volume(MVV) per minute, forced vital capacity(FVC) levels(P>0.05). At 1 d before operation, the research group had higher FEV1 as(2.13±0.25) L, MVV as(98.30±2.70) L and FVC as(2.62±0.19) L than(1.98±0.21),(92.70±1.97) and(2.36±0.28) L in the control group. Their difference was statistically significant(P<0.05). Both groups had no statistically significant difference in partial pressure of arterial oxygen(PaO2) and partial pressure of carbon dioxide(PaCO2) at admission(P>0.05). The research group had better PaO2 and PaCO2 at 1 d before operation and 7 d after operation than that at admission, and the difference was statistically significant(P<0.05). The control group had no statistically significant difference in PaO2 and PaCO2 at 1 d before operation and 7 d after operation, comparing with that at admission(P>0.05). The research group had better PaO2 and PaCO2 at 1 d before operation and 7 d after operation than the control group, and their difference was statistically significant(P<0.05). Both groups had no statistically significant difference in blood oxygen saturation(SaO2) at admission, 1 d before operation and 7 d after operation(P>0.05). At admis

关 键 词：异丙托溴铵 布地奈德 雾化吸入 肺癌 胸腔镜肺叶切除术 老年 

分 类 号：R734.2[医药卫生—肿瘤]