胃蛋白酶原联合肿瘤标志物CA199、CA125和CEA对胃癌的诊断价值分析  

Analysis of value of pepsinogen combined with tumor markers CA199, CA125 and CEA in diagnosis of gastric cancer

作　　者：孙运涛 SUN Yun-tao(Department of Clinical Laboratory , Guangdong Zhongshan Dongfeng Peoples' s Hospital, Zhongshan 528425, China)

机构地区：[1]广东省中山市东凤人民医院检验科

出　　处：《中国实用医药》2019年第16期22-23,共2页China Practical Medicine

摘　　要：目的分析胃蛋白酶原联合肿瘤标志物血清糖蛋白抗原199(CA199)、糖蛋白抗原125(CA125)和癌胚抗原(CEA)对胃癌的诊断价值。方法选取经过病例活检确诊的85例胃癌患者作为胃癌组,经确诊的81例胃炎、胃溃疡患者作为良性组,另选取同期86例健康人群作为参照组。测定并比较三组胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及血清肿瘤标志物(CA199、CA125和CEA)水平,比较联合联测与单一检测的特异度与敏感度。结果参照组与良性组PGⅠ、PGⅡ及CA199、CA125、CEA水平比较,差异无统计学意义(P>0.05);胃癌组PGⅠ(57.85±9.21)ng/ml和PGⅡ(20.74±3.76)ng/ml均显著低于参照组的(124.72±40.32)、(38.34±16.56)ng/ml和良性组的(116.98±60.68)、(35.00±6.00)ng/ml, CA199(61.90±9.76)U/L、CA125(53.43±8.92)U/L、CEA(34.76±4.78)ng/ml均显著高于参照组的(20.21±9.03)U/L、(9.61±4.01)U/L、(1.96±1.21)ng/ml 和良性组的(22.70 ±8.43)U/L、(10.98 ±8.37)U/L、(2.01±0.34)ng/ml,差异有统计学意义(P<0.05)。胃蛋白酶原、肿瘤标志物水平单一检测的特异度、敏感度均低于联合检测.差异有统计学意义(P<0.05)。结论胃癌诊断中,胃蛋白酶原联合肿瘤标志物CA199、CA125和CEA对胃癌的检测优于单一指标检测,值得临床借鉴。Objective To analyze the value of pepsinogen combined with tumor markers carbohydrate antigen 199(CA199), cancer antigen 125(CA125) and serum carcinoembryonic antigen(CEA) in diagnosis of gastric cancer. Methods There were 85 patients with gastric cancer confirmed by biopsy as the gastric cancer group, 81 patients with gastritis and gastric ulcer as the benign group, and 86 healthy people in the same period were selected as the control group. The levels of pepsinogen Ⅰ(PG Ⅰ), pepsinogen Ⅱ(PG Ⅱ) and serum tumor markers [carbohydrate antigen 199(CA199), cancer antigen 125(CA125) and serum carcinoembryonic antigen(CEA)] of three groups were measured and compared, and the specificity and sensitivity of combined and single detection were compared. Results There was no statistically significant difference in PGⅠ, PGⅡ, CA199,CA125 and CEA between control group and benign group(P>0.05). Gastric cancer group had significantly lower PGⅠ as(57.85±9.21) ng/ml and PGⅡ as(20.74±3.76) ng/ml than(124.72±40.32) and(38.34±16.56) ng/ml in control group and(116.98±60.68) and(35.00±6.00) ng/ml in benign group, and significantly higher CA199 as(61.90±9.76) U/L, CA125 as(53.43±8.92) U/L and CEA as(34.76±4.78) ng/ml than(20.21±9.03) U/L,(9.61±4.01) U/L and(1.96±1.21) ng/ml in control group and(22.70±8.43) U/L,(10.98±8.37) U/L and(2.01±0.34) ng/ml in benign group. Their difference was statistically significant(P<0.05). The specificity and sensitivity of single detection of pepsinogen and tumor markers were lower than that of combined detection, and the difference was statistically significant(P<0.05).Conclusion In the diagnosis of gastric cancer, the detection of pepsinogen combined with tumor markers CA199, CA125 and CEA is better than that of single index. It is worthy of clinical reference.

关 键 词：胃癌诊断 胃蛋白酶原 肿瘤标志物 

分 类 号：R735.2[医药卫生—肿瘤]