Nuclear actin switch of the IN080 remodeler  

作　　者：Jun Wu Yimin Lao Bing Li 

机构地区：[1]Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China [2]Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China

出　　处：《Journal of Molecular Cell Biology》2019年第5期343-344,共2页分子细胞生物学报（英文版）

基　　金：the National Key R&D Program of China(2018YFC1004500);the National Natural Science Foundation of China(31872817 to B.L).

摘　　要：Eukaryotic DNA is wrapped in nucleosomes, which impede the access of transcription factors and regulatory proteins to template DNA. Chromatin remodelers utilize the energy from ATP hydrolysis to drive histone movement relative to nucleosomal DNA and nucleosome editing. Thus, they play critical roles in transcription, DNA replication, and damage repair, and their dysfunctions are often associated with diseases including cancers (Klages-Mundt et al., 2018). Chromatin remodelers can be generally categorized into IN080, SWI/SNF, CHD, and ISWI subfamilies, which share conserved catalytic ATPasetranslocase motors. However, how other auxiliary components of these multi-subunit machinery control their genomic recruitment and actions of DNA translocation remains as a major challenge of the field.

关 键 词：EUKARYOTIC DNA NUCLEOSOMES of the FIELD 

分 类 号：Q[生物学]