Inflammatory bowel disease(IBD)is a progressive multifactorial inflammatory disease of the gut.The cause of IBD is yet unknown.Some researchers have shown that genetic factors,environmental factors,and the gut microbi...
Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the intes-tine.While the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immu...
supported by the National Natural Science Foundation of China(Nos.42276095,42188102,42141003,and U20A20103);the Open Innovation Fund for Undergraduate Students of Xiamen University,and Ocean Negative Carbon Emissions(ONCE)program。
Haptophytes(Eukaryota,Hacrobia)play a crucial role in the energy budget and element cycling of diverse aquatic ecosystems due to their ability to engage in both phototrophic and mixotrophic nutritional modes.Neverthel...
Mutagens are agents that cause damage to DNA and have the potential to permanently alter (mutate) its sequence, depending on the organism’s ability to repair the damage. UV radiation is a mutagen in cells. This mutag...
supported by the National Natural Science Foundation of China(Grant Nos.32270692,31801104,31571358);the National Key R&D Program of China(Grant No.2018YFA0903700).
DNA replication is a complex and crucial biological process in eukaryotes.To facilitate the study of eukaryotic replication events,we present a database of eukaryotic DNA replication origins(DeOri),which collects geno...
supported by Chinese National Natural Science Funds(31925013,U20A20393);a special programs from the Ministry of Science and Technology of China(2021YFA1101000).
In a recent study published in Cell,Litsios et al.revealed a highresolution spatiotemporal map of the eukaryotic cell cycle proteome.1 They identified proteome-level changes in both abundance and spatial distribution ...
supported by the National Natural Science Foundation of China(No.42077219);the Ningbo Municipal Natural Science Foundation(No.2019A610443);the Hangzhou Municipal Agriculture and Social Development Project(No.2020ZDSJ0697);the Fundamental Research Funds for the Provincial Universities of Zhejiang(No.SJLY2020011)
Globally,various types of pollution affect coastal waters as a result of human activities.Bioaugmentation and biostimulation are effective methods for treating water pollution.However,few studies have explored the res...
CD4^(+)T cells,particularly IL-17-secreting helper CD4^(+)T cells,play a central role in the inflammatory processes underlying autoimmune disorders.Eukaryotic Elongation Factor 2 Kinase(eEF2K)is pivotal in CD8^(+)T ce...
supported by the Nature Science Foundation of Hubei Province(No.2017CFB606).
Objective Aberrant activating mutations in cyclin-dependent kinases 4 and 6(CDK4/6)are common in various cancers,including gastroesophageal malignancies.Although CDK4/6 inhibitors,such as abemaciclib and palbociclib,h...
This work was financially supported by the National Natural Science Foundation of China(Project Nos.2030015,32270512);the Natural Science Foundation of Jiangsu Province(BK20220268);the Fundamental Research Funds for the Central Universities(GK202207014);a National Institutes of Health grant No.P40OD010964 subaward to NAS.The content is solely the responsibility of the authors and does not necessarily represent the ofcial views of the National Institutes of Health.Many thanks are given to Prof.Weibo Song(Ocean University of China[OUC])for his help during drafting the manuscript.We thank Ruitao Gong(OUC)for helping with species identifcation,DNA,and RNA extraction.We acknowledge the computing resources provided on the IEMB-1,a high-performance computing cluster operated by the Institute of Evolution and Marine Biodiversity,OUC.
One of the most diverse clades of ciliated protozoa,the class Spirotrichea,displays a series of unique characters in terms of eukaryotic macronuclear(MAC)genome,including high fragmentation that produces nanochromosom...