白头翁汤加味联合美沙拉嗪缓释片治疗热毒炽盛型溃疡性结肠炎的临床疗效观察  

Clinical Observation of Baitouweng decoction modified combined with Mesalazine sustained release tablets in the treatment of ulcerative colitis with hot toxicity and its effect on immune function and serum inflammatory factor in patients with ulcerative co

作　　者：马乾章[1] 李云[2] 丁原全 MA Qian-zhang;LI Yun;DING Yuan-quan(Department of Spleen and Stomach, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110000, Liaoning Provnce, China;Tacheng District People’s Hospital General Department of Medicine, Xinjiang Uygur Autonomous Region, 834700, China;People's Liberation Army Joint Service Support Team Dalian Rehabilitation Center Fujiazhuang Hospital, Alian, 116000, China)

机构地区：[1]辽宁中医药大学附属医院脾胃科,辽宁沈阳110000 [2]塔城地区人民医院全科医学科,新疆塔城834700 [3]解放军联勤保障部队大连康复疗养中心付家庄医院,辽宁大连116000

出　　处：《海南医学院学报》2019年第12期918-922,共5页Journal of Hainan Medical University

基　　金：辽宁省自然科学基金指导计划项目(20170540609)~~

摘　　要：目的:观察白头翁汤加味联合美沙拉嗪缓释片治疗热毒炽盛型溃疡性结肠炎的临床疗效及对患者免疫功能及血清炎症因子的影响。方法:收集84例UC患者,随机分为对照组与治疗组各42例。对照组给予美沙拉嗪缓释片口服,治疗组给予白头翁汤加味配合美沙拉嗪缓释片口服治疗。治疗周期为30 d,随访患者3个月。治疗后观察两组的临床疗效、生活质量改善、免疫功能改善、血清炎症因子变化情况。结果:治疗组治疗有效率高于对照组,差异具有统计学意义(P<0.05);两组IBDQ量表评分均较治疗前提高,观察组提高更明显,差异均具有统计学意义(P<0.05);两组治疗后血浆CD4+/CD8+比值与NK+水平均显著高于治疗前,治疗组改善更为显著,差异均具有统计学意义(P<0.05);经治疗两组血清肿瘤坏死因子(TNF-α)、白细胞介素-17(IL-17)、白细胞介素-23(IL-23)表达水平均明显下降,治疗组改善更为显著,差异均具有统计学意义(P<0.05);治疗组未观察到明显的不良反应。结论:白头翁汤加味联合美沙拉嗪治疗热毒炽盛型UC可以显著提高临床疗效,改善患者生活质量,有效调控UC患者血清炎症因子的表达水平,促进患者免疫功能的恢复,药物安全性高。Objective: To observe the clinical efficacy of Baitouweng decoction combined with mesalazine sustained-release tablets in the treatment of ulcerative colitis (UC) with febrile heat and its effect on immune function and serum inflammatory factors. Methods: 84 UC patients were randomly divided into control group and treatment group with 42 cases in each group. The control group was given Mesalazine sustained-release tablets orally, while the treatment group was given Baitouweng Decoction and Mesalazine sustained-release tablets orally. The treatment period was 30 days and the patients were followed up for 3 months. After treatment, the clinical efficacy, quality of life, immune function and serum inflammatory factors of the two groups were observed. Result: The effective rate of treatment group (90.47%) was higher than that of control group (73.81%)( P <0.05);compared with before treatment, the scores of IBDQ scale in both groups were significantly improved ( P <0.05), and the difference between the two groups was significant ( P <0.05);after treatment, the plasma CD4 +/CD8 + ratio and NK+ levels in both groups were significantly higher than those before treatment ( P <0.05), and the treatment group was changed. The serum levels of TNF-a, IL-17 and IL-23 were significantly decreased in both groups after treatment ( P < 0.05) and the improvement was more significant in the treatment group ( P <0.05). No significant adverse reactions were observed in the treatment group. Conclusion: Modified Baitouweng Decoction combined with mesalazine in the treatment of heat-toxic and incandescent UC can significantly improve the clinical efficacy, improve the quality of life of patients, effectively regulate the expression level of serum inflammatory factors in UC patients, promote the recovery of patients' immune function, and have high drug safety.

关 键 词：白头翁汤 美沙拉嗪缓释片 热毒炽盛 溃疡性结肠炎 免疫功能 血清炎症因子 

分 类 号：R574.62[医药卫生—消化系统]