AR表达与乳腺癌21基因复发风险评分的关系研究  

Relationship between AR expression and 21-gene recurrence score in breast cancer

作　　者：胡建军 杨文君[1] 孙习英 张著学[1] 易韦[1] Hu Jianjun;Yang Wenjun;Sun Xiying;Zhang Zhuxue;Yi Wei(Department of Pathology,Guizhou People's Hospital,Guizhou Guiyang,550002,Guizhou,China)

机构地区：[1]贵州省人民医院病理科

出　　处：《贵州医药》2019年第6期846-849,共4页Guizhou Medical Journal

基　　金：贵州省人民医院博士基金[GZSYBS(2017)03];贵州省科学技术基金项目[黔科合基础(2018)1103]

摘　　要：目的研究ER阳性、HER2阴性、腋窝淋巴结阴性的早期乳腺癌AR表达与21基因RS值之间的关系。方法选择行21基因检测的早期乳腺癌病例,采用免疫组织化学法检测AR在乳腺癌中的表达,并分析21基因RS值与AR表达等临床病理因素的关系。结果AR在ER阳性、HER2阴性、腋窝淋巴结阴性的早期乳腺癌中表达的阳性率为87.5%,主要定位于细胞核中。肿瘤直径(P=0.010)、AR表达(P=0.033)、PR表达(P=0.010)三个病理参数对RS值的影响差异有统计学意义。AR表达与21基因RS值的评分呈负相关(r=-0.327,P=0.0028),PR表达也与21基因RS值的评分呈负相关(r=-0.446,P=0.0034)。结论ER阳性、HER2阴性、腋窝淋巴结阴性的早期乳腺癌中AR表达与21基因RS值之间呈负相关,AR高表达21基因RS值较低。Objective To study the relationship between AR expression and 21-gene recurrence score in lymph node-negative,estrogen receptor-positive and HER2-negative breast cancer.Methods The expression of AR in breast cancer was detected by immunohistochemistry in early breast cancer patients that underwent 21gene detection,and the relationship between 21-gene recurrence score and AR expression and other clinicopathological factors were analyzed.Results The positive rate of AR in ER positive,HER2 negative and axillary lymph node negative early breast cancer was 87.5% and AR mainly localized in the nucleus.The influence of tumor diameter ( P =0.010),AR expression ( P =0.033) and PR expression ( P =0.010),on 21-gene recurrence score were statistically significant.The correlation analysis showed that AR expression ( r =-0.327,P =0.002 8) and PR expression( r =-0.446,P =0.003 4) had significant negative associations with RS.Conclusion AR expression is negatively correlated with the 21-gene recurrence score in ER positive,HER2 negative and axillary lymph node negative early breast cancer.

关 键 词：乳腺癌 21基因 复发风险评分 AR 

分 类 号：R737.9[医药卫生—肿瘤]