细胞分裂和癌变机制新假说  

A new hypothesis about cell division and carcinogenesis

作　　者：张丰 ZHANG Feng(Department of Pathology, Xijing Hospital and School of Basic Medicine, Air Force Military Medical University, Xi’an 710032, China)

机构地区：[1]空军军医大学西京医院病理科暨基础医学院病理学教研室

出　　处：《医学争鸣》2019年第3期31-33,共3页Negative

基　　金：国家自然科学基金(31000559,81572631)

摘　　要：细胞为何分裂,癌症如何发生,至今仍众说纷纭。本文通过分析细胞为什么会分裂,提出了关于细胞分裂和癌变新假说:细胞内渗透压缓慢升高推动细胞体积不断增大直至细胞膜无法支撑而“破裂”,这样周而复始的循环是细胞为什么会不断分裂的根本原因。癌变是由于肿瘤细胞内渗透压升高速度明显快于其起源正常细胞结果,所以肿瘤细胞更容易“破裂”,也就是分裂速度加快。最后,本文认为调节细胞内渗透压的方法可以应用于恶性肿瘤的治疗。由于肿瘤细胞渗透压增速并更容易“破裂”,因此,突然进一步升高肿瘤细胞内渗透压,可能导致肿瘤细胞“胀亡”,从而达到治疗的目的。Presently, there are still many controversies about the mechanism of cell division and carcinogenesis. Here, through exploring the question why cells can divide, the author presents a new hypothesis about cell division and carcinogenesis: slowly increased osmotic pressure within cells continually enlarges the cell volume until the tolerance limit of cell membranes to “split”, and such a cycle is the real cause of the continual cell division. Carcinogensis primarily results from the faster increase of osmotic pressure within cancer cells compared with that of the origin normal cells. Therefore, cancer cells get easier “rupture” or faster division. Based on the hypothesis, the author puts forward that the methods of regulating osmotic pressure within cells may be used to treat malignancies. Due to the faster increase of osmotic pressure and easier “rupture” of cancer cells, suddenly further increasing the osmotic pressure within cancer cells may kill them by oncosis.

关 键 词：渗透压 细胞分裂 癌变 

分 类 号：R73[医药卫生—肿瘤]