基于TCGA数据库的AIM2在结直肠癌中的表达分析及临床相关性研究  

Association between AIM2 expression and clinicopathological variables in colorectal cancer: Research based on TCGA data

作　　者：程先硕[1] 董建华[1] 杨之斌[1] 李云峰[1] 沈焘[1] 张旋[1] 杨芳[1] 罗慧 李强[1] Cheng Xianshuo;Dong Jianhua;Yang Zhibin;Li Yunfeng;Shen Tao;Zhang Xuan;Yang Fang;Luo Hui;Li Qiang(Department of Colorectal Surgery,the Third Affiliated Hospital of Kunming Medical University,Yunnan Cancer Hospital,Yunnan Kunming 650118,China)

机构地区：[1]昆明医科大学第三附属医院/云南省肿瘤医院结直肠外科

出　　处：《现代肿瘤医学》2019年第13期2334-2337,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81560472);云南省卫生厅-昆明医科大学联合专项[编号:2017FE468(-075)];云南省科技厅重点项目(编号:2018FA040);云南省结直肠肿瘤临床重点专科建设经费资助

摘　　要：目的:通过独立公开的TCGA数据库资源,探讨黑色素瘤缺乏因子2(AIM2)的表达与结直肠癌患者临床病理特征的相关性。方法:TCGA数据平台(https://portal.gdc.cancer.gov/)下载结直肠癌组织和正常组织AIM2基因表达数据及相关临床数据,并分析其表达与临床病理特征的关系。结果:癌组织中AIM2的表达显著低于正常对照组(P=0.0013),且正常对照组中AIM2的表达显著高于任何T分期、任何N分期以及任何M分期患者的癌组织(P<0.0001);癌组织中AIM2的表达与患者年龄、性别、肿瘤位置、T分期、N分期、M分期和病理分期均无明显相关(P>0.05),与患者5年总生存期无明显相关(P=0.4180);Ⅱ期患者癌组织中AIM2的表达显著高于IV期患者(P=0.0237)。结论:结直肠癌组织中AIM2的表达显著低于正常组织,但与患者T分期、N分期、M分期和患者5年总生存期无明显相关,Ⅱ期患者癌组织中AIM2的表达显著高于IV期患者,因此,AIM2的表达可能主要参与结直肠癌发生的早期过程。该结论仍需通过更多的研究进行验证。Objective:To investigate the association between absent in melanoma 2 (AIM2) expression and clinicopathological variables in colorectal cancer (CRC) based on TCGA data.Methods:Data about AIM2 gene expression in CRC was downloaded from TCGA platform (https://portal.gdc.cancer.gov/).Correlation between AIM2 expression and clinicopathological variables was analyzed.Results:Expression level of AIM2 in CRC was significantly lower than in normal control ( P =0.001 3),also higher expression of AIM2 was observed in normal control than in cancer cases with any T stage,N stage and M stage( P <0.000 1).AIM2 expression had no correlation with gender,age,tumor location,T stage,N stage,M stage,pathological stage and 5-year overall survival rates (5-OS),but higher expression of AIM2 was observed in stage Ⅱ than in stage Ⅳ( P =0.023 7).Conclusion:The expression level of AIM2 in cancer cases is lower than in normal control,but has no relation with clinicopathological variables and 5-OS in CRC,but the expression level of AIM2 is higher in stage Ⅱ than in stage IV.So,the expression of AIM2 might be involved in the early course of colorectal cancer.Further studies are warranted to confirm this conclusion.

关 键 词：黑色素瘤缺乏因子2 结直肠癌 TCGA 

分 类 号：R735.3[医药卫生—肿瘤]