进展性脑梗死患者血清CTRP3的表达及其与炎症因子的相关性  

Expression of serum CTRP3 in patients with progressive cerebral infarction and its correlation with inflammatory factors

作　　者：李柏林[1] 梁春娜[1] 谭文静 阮炎鹏 梁明俊[1] 谢富华[3] Li Bolin;Liang Chunna;Tan Wenjing;Ruan Yanpeng;Liang Mingjun;Xie Fuhua(Department of Emergency,Kaiping Central Hospital,Jiangmen 529300,China;Department of Neurology,Kaiping Central Hospital,Jiangmen 529300,China;Department of Critical Care Medicine,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510000,China)

机构地区：[1]开平市中心医院急诊科,江门529300 [2]开平市中心医院神经内科,江门529300 [3]广州医科大学附属第二医院重症医学科,广州510000

出　　处：《中华脑科疾病与康复杂志（电子版）》2019年第2期87-90,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

摘　　要：目的观察进展性脑梗死(PCI)患者血清C1q/TNF相关蛋白3(CTRP3)的变化水平并探讨其临床价值。方法选择开平市中心医院神经内科自2017年3月至2018年3月收治的PCI患者55例为研究组,55例健康体检者为对照组。酶联免疫吸附法(ELISA)检测研究组和对照组患者治疗前后肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和CTRP3的水平。结果治疗前研究组血清TNF-α、IL-6水平高于对照组(P<0.05),CTRP3水平低于对照组(P<0.05),CTRP3与TNF-α、IL-6水平呈负相关(r=-0.351,P=0.009;r=-0.465,P=0.003)。治疗后研究组TNF-α、IL-6水平较治疗前均降低,CTRP3水平增高,差异具有统计学意义(P<0.05),CTRP3与TNF-α、IL-6水平也呈负相关(r=-0.326,P=0.015;r=-0.569,P=0.001)。结论PCI患者血清CTRP3含量显著降低,治疗后水平增高,且与TNF-α、IL-6水平负相关,提示CTRP3可能参与PCI后脑损伤的病理生理过程,CTRP3的表达可能作为辅助判断PCI病情进展的一项指标。Objective To observe the changes of serum C1q/TNF-related protein 3(CTRP3)in patients with progressive cerebral infarction(PCI)and to explore its clinical value.Methods Fifty-five patients with PCI were selected as the research group,fifty-five healthy subjects were selected as the control group.The levels of tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6)and CTRP3 were compared between the two groups before and after treatment by enzyme-linked immunosorbent assay(ELISA).Results The levels of TNF-αand IL-6 in research group were higher than those in control group(P<0.05).The level of CTRP3 in the research group was lower than that in control group(P<0.05).CTRP3 has a negative correlation between TNF-αand IL-6 levels(r=-0.351,P=0.009;r=-0.465,P=0.003),respectively.After treatment,the levels of TNF-αand IL-6 in PCI group were decreased,and the level of CTRP3 was increased(P<0.05),CTRP3 has a negative correlation between TNF-αand IL-6 levels(r=-0.326,P=0.015;r=-0.569,P=0.001),respectively.Conclusion The level of serum CTRP3 in patients with PCI was decreased,and CTRP3 levels was increased after treatment,and it is negatively correlated with the levels of TNF-αand IL-6.It is suggested that CTRP3 may be involved in the pathophysiological process of brain injury after PCI.The detection of serum CTRP3 may have important clinical significance in assisting to judge the prognosis of PCI.

关 键 词：C1q/TNF相关蛋白3 进展性脑梗死 肿瘤坏死因子Α 白细胞介素6 

分 类 号：R743.3[医药卫生—神经病学与精神病学]