水通道蛋白与先天性白内障研究进展  

Research progress of aquaporin and congenital cataract

作　　者：赵靖康 刘旭[2] 何媛[2] Jing-Kang Zhao;Xu Liu;Yuan He(Xi’an Medical University, Xi’an 710016, Shaanxi Province, China;Department of Ophthalmology, the Second Affiliated Hospital of Xi’an Medical University, Xi’an 710038, Shaanxi Province, China)

机构地区：[1]西安医学院,中国陕西省西安市710016 [2]西安医学院第二附属医院眼科,中国陕西省西安市710038

出　　处：《国际眼科杂志》2019年第7期1126-1130,共5页International Eye Science

基　　金：国家自然科学基金项目(No.81100665,81770929);陕西省教育厅2018年服务地方科学研究计划(No.18JC026);陕西省科技厅项目(No.2019SF-162)~~

摘　　要：水通道蛋白(aquaporins,AQPs)主要介导自由水沿渗透压梯度被动跨生物膜转运,水通道蛋白在保持细胞内外环境的稳态平衡,完成生理功能方面发挥着重要的作用。晶状体纤维细胞中只表达三种水通道蛋白:AQP1、AQP0和AQP5,三种AQPs的不同功能及空间差异表达促进产生和调节微循环系统。AQPs相关基因的改变可导致白内障的发生。本文综述了近年来对AQP1、AQP0和AQP5研究,并讨论了其与先天性白内障发生的关系。Aquaporins (AQPs) mainly mediate passive transmembrane transport of free water along osmotic pressure gradient. Three aquaporins, AQP1, AQP0 and AQP5, expressed in lens fibroblasts. The different functions of AQPs play important roles in promoting the formation and regulation of microcirculatory system. Furthermore, mutations in AQP-related genes can lead to cataracts. This paper reviews the current research status of aquaporin, and discusses the relationship between aquaporin-related proteins and congenital cataract.

关 键 词：水通道蛋白 晶状体 先天性白内障 

分 类 号：R776.1[医药卫生—眼科]