绝经后女性宫颈人乳头状瘤病毒感染与宫颈病变的临床分析  

Cervical human papillomavirus infection and cervical lesions in postmenopausal women

作　　者：朱慧玲[1] 高燕[1] 金龙妹 张晓华 杨慧宾 张琳琳 曹晶 Zhu Huiling;Gao Yan;Jin Longmei;Zhang Xiaohua;Yang Huibin;Zhang Linlin;Cao Jing(Department of Gynecology,Huadong Hospital Affiliated to Fudan University,Shanghai 200040,China;Department of Gynecology,Minhang District Maternal and Child Health Hospital,Shanghai 201102,China)

机构地区：[1]复旦大学附属华东医院妇科,上海200040 [2]上海市闵行区妇幼保健院妇保科,201102

出　　处：《中华全科医师杂志》2019年第6期579-582,共4页Chinese Journal of General Practitioners

基　　金：上海市卫生和计划生育委员会科研课题资助项目(201440346).

摘　　要：对2017年上海市闵行区妇科普查者中20420例绝经后女性人乳头状瘤病毒(HPV)感染状况及宫颈病变情况进行分析。绝经后女性HPV阳性率为8.37%(1710/20420),以高危型HPV阳性为主,占95.26%(2029/2130),前4位亚型为HPV52、58、16、18型。≥65岁组HPV阳性率为7.37%(300/4069),<65岁组HPV阳性率为8.62%(1410/16351),差异有统计学意义(χ^2=6.640,P=0.010)。普查后共随访到有病理结果的患者552例,其中宫颈病变133例,其HPV亚型的前4位为HPV16、52、58、33型。≥65岁组宫颈病变占22.35%(40/179),<65岁组宫颈病变占24.93%(93/373),两组比较差异无统计学意义。社区妇女普查可考虑将HPV基因分型检测作为初筛,并对高危人群进行随访管理;终止筛查的年龄应适当延长。The status of human papillomavirus (HPV) infection and cervical lesions was analyzed among 20 420 postmenopausal women who participated in gynecological disease screening in Shanghai Minhang district 2017. The infection rate of HPV in postmenopausal women was 8.37%(1 710/20 420), and the infection of high-risk HPV 52,58,16,18 accounted for 95.26%(2 029/2 130). The HPV infection rate was 7.37% in women aged ≥65 years,and that was 8.62% in women aged<65 years(χ^2=6.640, P=0.010). Among 552 cases with pathological results there were 133 cases of cervical lesions. The top 4 HPV infections in patients with cervical lesions were HPV16,52,58 and 33. The rate of cervical lesions was 22.35% in ≥65 age group,and 24.93% in <65 age group (P>0.05). The study suggests that HPV genotyping should be taken into account in gynecological disease screening,and the subjects with high-risk HPV infection should be closely followed up;meanwhile,the age limits of screening population should be appropriately extended.

关 键 词：绝经后期 人乳头状瘤病毒 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]