纳米炭及亚甲蓝淋巴绘图在腹腔镜早期子宫内膜癌分期术中的比较观察  

Comparison of carbon nanoparticles and methylene blue for sentinel lymph node mapping in laparoscopic staging of early endometrial carcinoma

作　　者：金艳荣[1] 陈隈陟[1] 马唯[1] 李春玲 苗晓[1] Jin Yanrong;Chen Weizhi;Ma Wei;Li Chunling;Miao Xiao(Beijing Luhe Hospital Capital Medical University,Beijing 100049,China)

机构地区：[1]首都医科大学附属北京潞河医院妇产科,100049

出　　处：《中华全科医师杂志》2019年第6期583-586,共4页Chinese Journal of General Practitioners

摘　　要：将2016年1月至2018年1月北京潞河医院妇产科行腹腔镜子宫内膜癌分期术的45例临床Ⅰ、Ⅱ期子宫内膜癌患者,应用随机数字表分为亚甲蓝组(20例)及纳米炭组(25例),在腹腔镜下子宫内膜癌分期术中分别注射亚甲蓝及纳米炭对前哨淋巴结(SLN)进行示踪,比较两者的显影效果。纳米炭组显影时间(16.4±3.4)min、持续时间(73.1±14.3)min,均优于亚甲蓝组的(21.0±5.9)min、(54.6±14.9)min,差异有统计学意义(t=3.26,P<0.01;t=4.20,P<0.01)。亚甲蓝和纳米炭组的SLN检出率为5/18与95%(21/22),灵敏度为1/2和4/4(χ^2=66.70,P<0.01),差异有统计学意义(P=0.05)。亚甲蓝及纳米炭示踪SLN可应用于腹腔镜早期子宫内膜癌分期术,纳米炭示踪SLN可作为术中预测盆腔淋巴结转移的首选方法。To compare carbon nanoparticles with methylene blue for sentinel lymph nodes mapping in laparoscopic staging of early endometrial carcinoma. Forty five patients with stage Ⅰ or stage Ⅱ endometrial carcinoma undergoing laparoscopic operation from January 2016 to January 2018 were randomly divided into two groups:methylene blue was applied in 20 cases and carbon nanoparticies were applied in 25 cases for sentinel lymph node (SLN) mapping in laparoscopic staging;and the images of two tracers were compared. The development time of nano-carbon group was shorter[(16.4±3.4) min vs.(21.0±5.9)min,t=3.26, P=0. 02] and duration was longer [(73.1±14.3) min vs.(54.6±14.9)min, t=5.41, P=0.04] than those of methylene blue group. In lymphatic mapping, the detection rate of SLN in nano-carbon group was significantly higher than that of methylene blue group [95%(21/22) vs. 5/18]. For detection of metastatic SLN,the sensitivity of methylene blue group was 1/2 and that of nano-carbon group was 4/4 (χ^2=66.70, P<0.01). The results indicate that both methylene blue and Nano-carbon tracer can be used for SLN mapping in laparoscopic staging of early endometrial carcinoma, and nano-carbon tracer is recommended as the first choice to predict pelvic lymph node metastasis in endometrial carcinoma surgery.

关 键 词：子宫内膜肿瘤 癌 前哨淋巴结 纳米炭 亚甲蓝 

分 类 号：R737.33[医药卫生—肿瘤]