精神分裂症患者社会支持程度与血清神经功能指标水平及阴性症状、抑郁症状的相关性  

Correlation between social support and serum neurological function indicator levels, negative symptoms and depressive symptoms in schizophrenic patients

作　　者：辛一帆 李光梅[1] 郑兴华 Xin Yifan;Li Guangmei;Zheng Xinghua(Department of Psychiatry,Panzhihua Third People's Hospital,Panzhihua 617061,China)

机构地区：[1]攀枝花市第三人民医院精神科,617061

出　　处：《神经疾病与精神卫生》2019年第4期371-376,共6页Journal of Neuroscience and Mental Health

基　　金：四川省卫生厅科研项目(100346).

摘　　要：目的探讨精神分裂症患者社会支持程度与血清神经功能指标水平、阴性症状及抑郁症状的相关性。方法2014年9月至2018年6月攀枝花市第三人民医院收治的首发精神分裂症患者92例,参照随机数表法将人组患者分为对照组、研究组各46例。对照组患者常规服用抗精神病药物,研究组患者接受社会支持干预+抗精神病药物治疗,持续1个月后进行效果评估。对比两组患者干预前后社会支持评定量表(SSRS)评分,同时研究组根据干预后SSRS评分中位数进一步被分为高SSRS评分组、低SSRS评分组各23例。对比对照组、研究组,研究组不同SSRS评分组间血清神经递质[多巴胺(DA)、7-氨基丁酸(GABA)、乙酰胆碱(Ach)]、神经营养因子[脑源性神经营养因子(BDNF)、神经生长因子(NGF)]的含量,阴性症状量表(SANS)、卡尔加里精神分裂症抑郁量表(CDSS)评分值的差异。结果干预后,研究组的SSRS评分值高于对照组;DA、GABA的含量高于对照组,Ach的含量低于对照组;BDNF、NGF的含量高于对照组;SANS、CDSS评分值低于对照组(P<0.05)。高SSRS评分组的上述指标变化幅度均大于低SSRS评分组(P<0.05)。结论社会支持干预可有效优化精神分裂症患者的病情,社会支持程度可能是影响患者病情的重要因素之一。Objectives To investigate the relationship between social support and serum neurological function level, negative symptoms and depressive symptoms in patients with schizophrenia. Methods From September 2014 to June 2018, a total of 92 patients with first-episode schizophrenia admitted to Panzhihua Third People s Hospital were divided into the control group and the study group with 46 patients in each group according to the random number table method. Patients in the control group were routinely taking antipsychotic drugs, and patients in the study group received social support intervention and antipsychotic medication, and the effect was evaluated after one month. The Social Support Rating Scale (SSRS) scores before and after intervention were compared between the two groups. The study group was further divided into high SSRS score group and low SSRS score group with 23 cases in each group, according to the median SSRS score after the intervention. The differences in serum neurotransmitters [ dopamine (DA), 7 -aminobutyric acid (GABA), acetylcholine (Ach)], neurotrophic factor [ brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF)], Scale for the Assessment of Negative symptoms (SANS) scores, and the Calgary Depression Scale for Schizophrenia (CDSS) scores were compared across the control group, the study group and high and low SSRS score groups. Results The SSRS scores of the study group were higher than those of the control group. The level of DA and GABA was higher than that of the control group. The level of Ach was lower than that of the control group. The level of BDNF and NGF was higher than that of the control group. The scores of SANS and CDSS were lower than those of the control group (P <0.05). The change of the above indicators before and after the intervention of the high SSRS score group was larger than the low SSRS score group (P<0.05). Conclusions Social support intervention can effectively optimize the condition of patients with schizophrenia. The degree of social support may be on

关 键 词：精神分裂症 社会支持 神经功能 阴性症状 抑郁症状 

分 类 号：R749.3[医药卫生—神经病学与精神病学]