罗汉果及其功能成分干预糖脂代谢异常的分子机理研究进展  

Advances in Molecular Mechanism of Siraitia grosvenorii and Its Functional Components on the Abnormal Effects of Glucose and Lipid Metabolism

作　　者：唐敏怡 黎勇 吕承豪 覃思[1,2] TANG Min-yi;LI Yong;LV Cheng-hao;QIN Si(College of Food Science and Technology,Hunan Agricultural University,Changsha 410128,China;Faculty of Agriculture,Kagoshima University,Kagoshima-en 8900065,Japan)

机构地区：[1]湖南农业大学食品科学技术学院,湖南长沙410128 [2]鹿儿岛大学农学部,九州鹿儿岛8900065

出　　处：《食品工业科技》2019年第12期341-346,353,共7页Science and Technology of Food Industry

基　　金：国家自然科学基金青年基金项目(31101268);湖南省重点研发计划项目(2017NK2093)

摘　　要：罗汉果不仅是一种新型的功能性甜味剂,还是一种具有多种生理功能的传统药食两用中药材。本文首先综述了近年来国内外学者对罗汉果的生长特性、其主要功能成分的分类、生物活性及其功能产品的研发和应用现状,然后介绍了罗汉果及其功能成分在体内的消化、吸收、代谢及药物动力学等特性,最后重点总结了罗汉果及其功能成分干预糖脂代谢异常的动物及人体效果并在细胞层次分析了其可能存在的分子机制。本文为罗汉果及其功能成分的进一步研究与开发,特别是其在临床上的广泛应用提供扎实的理论指导和可靠的分子依据。Siraitia grosvenorii is not only a new type of functional sweetener,but also a kind of traditional Chinese medicine with multiple physiological functions. This paper firstly analyzes the growth characteristics of Siraitia grosvenorii,the classification,the biological activity,the development and the application status of its functional components. Secondly,analyzes the digestion,absorption,metabolism and pharmacokinetic properties of Siraitia grosvenorii and its active components based on a plenty of researches. Finally,focuses on the effects of Siraitia grosvenorii and its functional components on the abnormal effects of glucose and lipid metabolism in animals and human body and analyzes its possible molecular mechanisms at the cellular level. This paper provides a solid theoretical guidance and reliable molecular basis for the further research and development of Siraitia grosvenorii and its functional components,especially its wide application in clinical practice.

关 键 词：罗汉果 功能成分 糖脂代谢 干预 分子机理 

分 类 号：TS255.1[轻工技术与工程—农产品加工及贮藏工程]