35种中药饮片黄曲霉毒素B1的含量考察  

Study on the content of aflatoxin B1 in 35 traditional Chinese medicine decoction pieces

作　　者：沈紧治[1] 王政[1] 苏玉纯 Shen Jinzhi;Wang Zheng;Su Yuchun(Department of Pharmacy, Zhongshan Hospital, Xiamen University, Xiamen 361004, China)

机构地区：[1]厦门大学附属中山医院药学部,361004

出　　处：《国际中医中药杂志》2019年第6期614-617,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的考察常用中药饮片感染黄曲霉毒素 B1 的情况,为制订中药质量标准和科学管理提供参考。方法采用免疫亲和柱净化洗脱结合柱后光化学衍生法对 35 种中药饮片黄曲霉毒素 B1 含量进行检测。结果有 17 种中药饮片存在不同程度的黄曲霉毒素 B1 污染,污染率为 48.57%,其中胖大海、小茴香、延胡索黄曲霉毒素 B1 含量超标,其余受污染品种黄曲霉毒素 B1 含量均小于 1 μg/kg。结论所测中药饮片受黄曲霉毒素污染率高,中药饮片黄曲霉毒素 B1 污染程度与用药部位、产地有一定相关性。建议在《中华人民共和国药典》小茴香、延胡索的检查项下增加黄曲霉毒素的含量限量测定,以更好地控制其质量。Objective To investigate the contamination of aflatoxin B1 in traditional Chinese medicine decoction pieces.and to provide evidence for the development of sdandards and scientific management. Methods Immunoaffinity column and post-column photochemical derivatization were used to detect and quantify aflatoxin B1 in 35 traditional Chinese medicines. Results A total of 48.57%(17 out of 35 batches) traditional Chinese medicine were contained aflatoxin B1. The contents of aflatoxin B1 in all contaminated varieties were less than 1μg/kg, except for Sterculia lychnophorae Semen, Foeniculi Fructus, Corydalis Rhizoma, which exceeded the standard. Conclusions The tested traditional Chinese medicine are highly contaminated of aflatoxin, it is necessary to further study the increase of aflatoxin content under the examination of Chinese Pharmacopoeia Foeniculi Fructus and Corydalis Rhizoma to better control its quality. The degree of aflatoxin B1 pollution is reated to the site of drug use and the place of origin.

关 键 词：含量测定(中药) 黄曲霉毒素 B1 免疫亲和柱 光化学衍生法 

分 类 号：R284.1[医药卫生—中药学]