神经肌肉接头参与肌肉萎缩的研究现状  

Research status of neuromuscular junction in muscular atrophy

作　　者：王文康 谢鹏 Wang Wenkang;Xie Peng(Department of Critical Care Medicine,the Second Affiliated Hospital of Zunyi Medical University,Zunyi 563099,China)

机构地区：[1]遵义医科大学第二附属医院重症医学科,贵州遵义563099

出　　处：《中国实用医刊》2019年第8期118-120,共3页Chinese Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(31660290,31360256).

摘　　要：肌肉萎缩是一组进行性骨骼肌细胞退化疾病,主要表现为肌肉质量减少及肌肉功能减退,常见原因包括长期营养不良、废用、去神经支配等。临床上常继发于消耗性疾病,也可见于各种神经肌肉疾病。神经肌肉接头(NMJ)作为运动神经元末梢与骨骼肌之间的"桥梁",在肌肉萎缩过程中发挥了关键作用。本综述主要介绍肌肉萎缩患者神经肌肉接头功能的改变及其在临床方面的应用,旨在为后续研究提供思路及参考。Muscle atrophy is a group of progressive skeletal muscle cell degeneration diseases,mainly characterized by decreased muscle mass and muscle dysfunction.Common causes include chronic malnutrition,disuse,and denervation.Clinically,it is often secondary to wasting diseases,and can also be seen in various neuromuscular diseases.The neuromuscular junction(NMJ)acts as a"bridge"between motor neuron terminals and skeletal muscle and plays a key role in muscle atrophy.This review describes the changes in NMJ function in patients with muscle wasting and its clinical application,and aims to provide ideas and references for subsequent research.

关 键 词：神经肌肉接头 肌肉萎缩 萎缩相关基因 聚集蛋白 

分 类 号：R746.4[医药卫生—神经病学与精神病学]