小牛血清去蛋白注射液联合尼莫地平对急性脑出血患者神经功能及氧化应激反应的影响  

Effects of deproteinised calf blood serum injection combined with nimodipine on neurological function and oxidative stress reaction in patients with acute cerebral hemorrhage

作　　者：卢荣璋[1] 张志宏[1] 连伟杰 LU Rong-zhang;ZHANG Zhi-hong;LIAN Wei-jie(No.1 Neurosurgery Section,Shantou Central Hospital,Shantou 515041,China)

机构地区：[1]汕头市中心医院神经外科一区

出　　处：《临床医学研究与实践》2019年第18期10-12,共3页Clinical Research and Practice

摘　　要：目的探讨小牛血清去蛋白注射液联合尼莫地平对急性脑出血患者神经功能及氧化应激反应的影响。方法选择本院收治的104例急性脑出血患者作为研究对象,按急救方式的不同将其分成对照组和观察组,各52例。参见《中国脑出血诊治指南(2014)》给予两组患者西医常规治疗;对照组给予尼莫地平注射液;观察组在对照组的基础上给予小牛血清去蛋白注射液。两组均连续治疗2周。比较两组NIHSS、GCS评分、临床疗效以及血清MDA、SOD、GSH-Px水平。结果治疗后,两组患者的NIHSS评分均显著降低,GCS评分均显著升高,且观察组优于对照组,差异具有统计学意义(P<0.05);观察组患者的治疗总有效率为94.23%,高于对照组的78.85%,差异具有统计学意义(P<0.05);治疗后,观察组患者血清MDA水平显著低于对照组,SOD、GSH-Px水平显著高于对照组,差异具有统计学意义(P<0.05)。结论小牛血清去蛋白针联合尼莫地平可明显改善急性脑出血患者的神经功能,提高临床疗效,患者的氧化应激反应调节改善。Objective To investigate the effects of deproteinised calf blood serum injection combined with nimodipine on neurological function and oxidative stress reaction in patients with acute cerebral hemorrhage. Methods A total of 104 patients with acute cerebral hemorrhage admitted in our hospital were selected as the research objects. The patients were divided into control group and observation group according to different emergency treatment methods, with 52 cases in each group. Two groups were treated with conventional western medicine reference to Chinese guidelines for diagnosis and treatment of cerebral hemorrhage(2014). The control group was treated with nimodipine injection. On the basis of the control group, the observation group was treated with deproteinised calf blood serum injection. Both groups were treated for 2 weeks. The scores of NIHSS and GCS, clinical efficacy and serum levels of MDA, SOD and GSH-Px were compared between the two groups. Results After treatment, the NIHSS scores of the two groups decreased significantly, and the GCS scores increased significantly, and those in the observation group were better than the control group, and the differences were statistically signficant (P<0.05). The total effective rate of treatment in the observation group was 94.23%, which was higher than 78.85% in the control group, and the difference was statistically signficant (P<0.05). After treatment, the level of serum MDA in the observation group was significantly lower than that in the control group, and the levels of SOD and GSH-Px in the observation group were significantly higher than those in the control group, and the differences were statistically signficant (P<0.05). Conclusion Deproteinised calf blood serum injection combined with nimodipine can significantly improve the neurological function of patients with acute cerebral hemorrhage, increase the efficacy, and improve of the oxidative stress reaction of patients.

关 键 词：小牛血清去蛋白注射液 尼莫地平 急性脑出血 氧化应激反应 

分 类 号：R743.34[医药卫生—神经病学与精神病学]