鼻咽癌转移相关的信号通路  

Signaling pathway of associated with metasis of naopharynged carcinoma

作　　者：刘洁[1,3] 徐冰雁 胡晶 戴娜[1,3] 何迎春 胡梅[2,3] LIU Jie;XU Bingyan;HU Jing;DAI Na;HE Yingchun;HU mei(School of Postgraduate ,Hunan university of traditional Chinese medicine,Changsha,Hunan,410208;School of medicine,Hunan university of traditional Chinese medicine,Changsha,Hunan;Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine,Changsha,410208,Hunan)

机构地区：[1]湖南中医药大学研究生学院,湖南长沙410208 [2]湖南中医药大学医学院 [3]中医药防治眼耳鼻喉疾病湖南省重点实验室

出　　处：《中国中西医结合耳鼻咽喉科杂志》2019年第3期237-240,共4页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：国家自然科学基金课题(81573721和81874408);湖南省自然科学基金项目(2017JJ3246和2016JJ6117);长沙市科技计划项目(KC1704005);湖南省研究生科研创新项目(CX2017B482);湖南中医药大学研究生创新项目(2017CX33)

摘　　要：鼻咽癌晚期向其它脏器或部位转移是导致癌症患者死亡的主要原因,因此,抑制肿瘤转移是提高癌症患者生存几率的必要条件,近年来,鼻咽癌的靶向治疗越来越受到相关领域和研究人员的关注。鼻咽癌发生转移主要受其涉及的肿瘤转移基因与肿瘤转移抑制基因、肿瘤血管生成、细胞外基质降解、细胞黏附等因素影响,且相关信号通路参与了此过程,目前鼻咽癌转移的信号通路研究得较多的有:Wnt、MAPK、PI3K、JAK/STAT、TGF-β,本文围绕以上5条信号通路的分子机制进行综述。Metastasis of advanced nasopharyngeal carcinoma(NPC)to other organs or parts is the major cause of death among such patients,and therefore,inhibition of tumor metastasis is a necessary condition to improve the chances of survival for snch patients duning recent years,targeted therapy of NPC is more and more luterestod by researchers and related fields.Metastasis of NPC is mainly involved in tumor metastasis gene and tumor metastasis suppressor gene,angiogenesis,degradation of extracellular matrix,cell adhesion and some other factors,and related signaling pathway is involved in this process,the Metastasis of NPC inovlves soueral signaling pathway sachas Wnt,MAPK,PI3K,JAK/STAT,and TGF-β,This article around is focused on the above five signaling pathways to summarized the progress in their molecular mechanism.

关 键 词：鼻咽癌转移 信号通路 分子机制 

分 类 号：R739.63[医药卫生—肿瘤]