帕金森病发病机制及其早期诊断的研究进展  

Progress in pathogenesis and early diagnosis of Parkinson′s disease

作　　者：钟瑞霞 秦雅静 陈忠彦 张景童 赵淑珍 刘洋[3] Zhong Ruixia;Qin Yajing;Chen Zhongyan;Zhang Jingtong;Zhao Shuzhen;Liu Yang(Brain Center of Armed Police Characteristic Medical Center, Tianjin 300162, China;The Sixth Team of the Second Corps of Student Soldiers, Logistics Uninversity of PAP Force, Tianjin 300162, China;Department of Neurology, the Fourth People′s Hospital of Shanghai, Shanghai 200081, China)

机构地区：[1]武警特色医学中心脑科中心,天津300162 [2]武警后勤学院学兵二大队六队,天津300162 [3]上海市第四人民医院神经内科,200081

出　　处：《中国综合临床》2019年第3期276-280,共5页Clinical Medicine of China

基　　金：国家自然科学基金(31200809);天津市科技支撑计划项目(16ZXHLSY00120).

摘　　要：帕金森病是一种常见的中枢神经系统退行性疾病,主要病理特征是多巴胺能神经元的减少,诱发静止性震颤、肌强直、运动迟缓及姿势障碍等临床运动症状。帕金森病的具体病因及发病机制十分复杂,目前发病机制主要与线粒体功能障碍、氧化应激、神经炎性反应、凋亡及自噬等相关。帕金森病早期起病隐匿,误诊率较高,需要新的简单、安全有效的早期诊断方法,目前研究的早期诊断方法主要包括临床非运动症状、生物标记物以及影像检查方法。Objective Parkinson′s disease (PD) is a common degenerative disease of the central nervous system.The main pathological feature is the reduction of dopaminergic neurons, which induces motion symptoms such as resting tremor, muscle rigidity, bradykinesia, and postural disorder.The etiology and pathogenesis of PD are complex and related to a variety of factors.The current pathogenesis is related to mitochondrial dysfunction, oxidative stress, neuroinflammatory response, apoptosis, and autophagy.The early onset of PD is occult and the rate of misdiagnosis is high.It requires a new simple, safe, and effective early diagnosis method.The current methods of early diagnosis mainly include clinical non-motor symptoms, biomarkers, and imaging examination methods.

关 键 词：帕金森病 线粒体功能障碍 氧化应激 生物标记物 

分 类 号：R742.5[医药卫生—神经病学与精神病学]