急性缺血性脑卒中患者血清Hcy、GAL3、MCP-1表达及其临床意义  

Expression of serum Hcy,GAL3 and MCP-1 in patients with acute ischemic stroke and its clinical significance

作　　者：葛冰磊 俞善春 金纪伟 Ge Binlei;Yu Shanchun;Jin Jiwei(Department of Laboratory, Xuancheng People's Hospital, Xuancheng 242000, China)

机构地区：[1]安徽省宣城市人民医院检验科

出　　处：《中国医师杂志》2019年第6期893-897,共5页Journal of Chinese Physician

摘　　要：目的探讨急性缺血性脑卒中(ACIS)患者血清同型半胱氨酸(Hcy)、半乳糖凝集素3(GAL3)、单核细胞趋化蛋白1(MCP-1)表达及其临床意义。方法选择2016年1月至2018年2月本院ACIS患者100例为观察组,同期选取本院64例健康体检者为对照组。检测比较两组血清Hcy、GAL3、MCP-1水平,并检测观察组不同病变程度、不同脑梗死面积、不同预后患者的血清Hcy、GAL3、MCP-1水平,并分析血清Hcy、GAL3、MCP-1水平与ACIS脑梗死面积、神经功能缺损程度评分(NIHSS)的相关性,比较血清Hcy、GAL3、MCP-1单独及联合诊断ACIS的灵敏度、特异度、准确性。结果观察组血清Hcy、GAL3、MCP-1水平均高于对照组(P <0. 05);观察组不同病变程度患者血清Hcy、GAL3、MCP-1水平比较,差异有统计学意义(P <0. 05),且重度损伤患者上述指标水平高于中度损伤患者,中度损伤患者高于轻度损伤患者(P <0. 05);观察组不同脑梗死面积患者血清Hcy、GAL3、MCP-1水平比较,差异有统计学意义(P <0. 05),且大面积梗死患者上述指标水平高于中等面积梗死患者,中等面积梗死患者高于小面积梗死患者(P <0. 05);观察组死亡患者血清Hcy、GAL3、MCP-1水平高于存活患者(P <0. 05);相关性分析显示,血清Hcy、GAL3、MCP-1水平与ACIS脑梗死面积、NIHSS评分均呈正相关(P <0. 05);采用血清Hcy、GAL3、MCP-1联合诊断ACIS的灵敏度(91. 00%)及准确性(83. 54%)均高于单一指标诊断(P <0. 05)。结论急性缺血性脑卒中患者血清Hcy、GAL3、MCP-1水平均呈高表达,且其水平和患者病变程度、脑梗死面积、预后等密切相关,采取三者联合检测能提高诊断准确性及灵敏度,可将其作为急性缺血性脑卒中临床诊断、病情及预后评定的有效指标。Objective To investigate the expression and clinical significance of serum homocysteine( Hcy),galectin-3( GAL3) and monocyte chemotactic protein-1( MCP-1) in patients with acute ischemic stroke( ACIS). Methods 100 patients with ACIS in our hospital from January 2016 to February 2018 were selected as the observation group,and 64 healthy persons in our hospital were selected as the control group during the same period. The levels of serum Hcy,GAL3 and MCP-1 were detected and compared between the two groups. The levels of serum Hcy,GAL3 and MCP-1 in patients with different pathological changes,different cerebral infarction areas and different prognosis in the observation group were compared. The correlation between serum Hcy,GAL3 and MCP-1 levels and ACIS cerebral infarction area and neurological deficit scale( NIHSS) was analyzed. The sensitivity,specificity and accuracy of MCP-1 in diagnosing ACIS alone and in combination. Results The levels of serum Hcy,GAL3 and MCP-1 in the observation group were higher than those in the control group( P < 0. 05). There were significant differences in serum Hcy,GAL3 and MCP-1 levels between the patients with different pathological degrees of disease( P < 0. 05). The level of the above-mentioned indicators in patients with severe injury was higher than that in patients with moderate injury. The patients with moderate injury were higher than those with mild injury( P < 0. 05). There were significant differences in serum Hcy,GAL3 and MCP-1 levels in patients with different cerebral infarction areas( P < 0. 05),and the above-mentioned index level of patients with large-area infarction was higher than that of patients with moderate-area infarction. The patients with moderate-area infarction were higher than those with small-area infarction( P < 0. 05). The levels of serum Hcy,GAL3 and MCP-1 in the dead patients in the observation group were higher than those in the survivors( P < 0. 05);correlation analysis showed that serum Hcy,GAL3,MCP-1 levels were positively correlated with ACIS

关 键 词：脑缺血 卒中 高半胱氨酸 半乳糖凝集素3 趋化因子CCL2 

分 类 号：R743.3[医药卫生—神经病学与精神病学]