Trimetazidine in angina and poor muscle function: protocol for a randomized controlled study  

作　　者：Yu-Jie Zhang Jing-Xin Wang Shi-Hui Fu Xiao-Ying Li 

机构地区：[1]Department of Geriatric Cardiology,Chinese People's Liberation Army General Hospital,Beijing 100853,China [2]Department of Rehabilitation,Zhengzhou Central Hospital,Zhengzhou University,Zhengzhou,Henan 450007,China [3]Department of Rehabilitation,Chinese People's Liberation Army General Hospital,Beijing 100853,China

出　　处：《Chinese Medical Journal》2019年第12期1461-1466,共6页中华医学杂志（英文版）

摘　　要：Background: Low handgrip strength (HS) and declining gait speed (GS) are increasingly obvious with aging, requiring effective, and safe medication for treatment. Trimetazidine (TMZ) modified release tablets, a common anti-angina drug, has potential benefits for alleviating the condition, but this has not yet been fully studied and therefore is the aim of this study. Methods: This is a prospective randomized controlled study. Fifty-eight eligible patients will be randomly assigned to one of two study groups: TMZ group or control group. For the TMZ group, a dose of 35 mg of oral TMZ will be administered with a meal twice a day for 3 months, in addition to any conventional treatments for angina. Only conventional treatments for angina will be administrated in the control group. The primary outcome will be the 6-min walking distance and the secondary outcomes will be: muscle strength (HS and pinch strength), GS, muscle endurance (five times sit-to-stand test), balance maintenance (tandem standing test), and the frequency of angina per week. Additionally, body mass index, circumferences (biceps, waist, hip, and calf), albumin levels, and the score on a five-question scale for sarcopenia will be obtained during the study. Discussion: This study aims to evaluate the usefulness of TMZ in a population with poor muscle function. The results may provide an effective and safe medical treatment to people with low muscle strength or physical performance.

关 键 词：TRIMETAZIDINE ANGINA STRENGTH PHYSICAL performance 

分 类 号：R[医药卫生]