尼莫地平联合注射用鼠神经生长因子对脑出血患者脑水肿带体积、神经功能及血清炎性因子水平的影响  

Impact of Nimodipine Combined with Rat Nerve Growth Factor for Injection on Volume of Cerebral Edema Band,Neurological Function and Serum Inflammatory Cytokines Levels in Patients with Cerebral Hemorrhage

作　　者：王金梅[1] 刘佳[2] 石富铭[1] WANG Jinmei;LIU Jia;SHI Fuming(Department of Neurology,the People's Hospital of Daxing District,Beijing,Beijing 102600,China;Department of Ultrasonography,the People's Hospital of Daxing District,Beijing,Beijing 102600,China)

机构地区：[1]北京市大兴区人民医院神经内科,102600 [2]北京市大兴区人民医院超声科,102600

出　　处：《实用心脑肺血管病杂志》2019年第5期109-111,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的 探讨尼莫地平联合注射用鼠神经生长因子对脑出血患者脑水肿带体积、神经功能及血清炎性因子水平的影响。方法 选取2017年3月—2018年3月北京市大兴区人民医院收治的脑出血患者120例,采用随机数字表法分为对照组和研究组,每组60例。对照组患者给予常规治疗,研究组患者在常规治疗基础上给予尼莫地平联合注射用鼠神经生长因子治疗。比较两组患者治疗前后脑水肿带体积、美国国立卫生研究院卒中量表(NIHSS)评分及血清肿瘤坏死因子α(TNF-α)、白介素1β(IL-1β)水平,并观察两组患者治疗期间不良反应发生情况。结果 治疗前两组患者脑水肿带体积、NIHSS评分及血清TNF-α、IL-1β水平比较,差异无统计学意义(P>0.05);治疗后研究组患者脑水肿带体积小于对照组,NIHSS评分及血清TNF-α、IL-1β水平低于对照组(P<0.05)。两组患者治疗期间均未出现明显药物不良反应。结论 尼莫地平联合注射用鼠神经生长因子可有效缩小脑出血患者脑水肿带体积、减轻神经功能缺损程度、降低血清炎性因子水平,有利于保护神经元,改善患者神经功能及预后,且安全性较高。Objective To investigate the impact of nimodipine combined with rat nerve growth factor for injection on volume of cerebral edema band,neurological function and serum inflammatory cytokines levels in patients with cerebral hemorrhage.Methods From March 2017 to March 2018,a total of 120 patients with cerebral hemorrhage were selected in the People's Hospital of Daxing District,Beijing,and they were divided into control group and study group according to random number table,with 60 cases in each group.Patients in control group received routine treatment,while patients in study group received nimodipine combined with rat nerve growth factor for injection.Volume of cerebral edema band,NIHSS score,serum levels of TNF-αand IL-1βwere compared between the two groups before and after treatment,and incidence of adverse drug reactions was observed during treatment.Results No statistically significant difference of volume of cerebral edema band,NIHSS score,serum level of TNF-αor IL-1βwas found between the two groups before treatment(P>0.05);after treatment,volume of cerebral edema band in study group was statistically significantly smaller than that in control group,meanwhile NIHSS score,serum levels of TNF-αand IL-1βin study group were statistically significantly lower than those in control group(P<0.05).No one in the two groups occurred any obvious adverse drug reactions during treatment.Conclusion In patients with cerebral hemorrhage,nimodipine combined with rat nerve growth factor for injection can effectively shrink the volume of cerebral edema band,reduce the degree of neurological deficit and serum inflammatory cytokines levels,is helpful to protect the neurons,improve the neurological function and prognosis,with relatively high safety.

关 键 词：脑出血 尼莫地平 神经生长因子 治疗结果 炎性因子 

分 类 号：R743.34[医药卫生—神经病学与精神病学]