米那普仑与艾司西酞普兰治疗初发抑郁症的疗效比较  

Clinical efficacy of milnacipran versus escitalopram in patients with primary depression

作　　者：肖长久[1] 谭常赞[1] 杜颖[1] 程国强[1] 罗端庆 吕杏放[1] XIAO Chang-jiu;TAN Chang-zan;DU Ying;CHENG Guo-qiang;LUO Duan-qing;LV Xing-fang(Zhaoqing ThirdPeople’s Hospital,Zhaoqing 526060,China)

机构地区：[1]广东省肇庆市第三人民医院

出　　处：《广东医科大学学报》2019年第3期318-320,共3页Journal of Guangdong Medical University

摘　　要：目的比较米那普仑与艾司西酞普兰治疗初发抑郁症的临床疗效及不良反应。方法64例初发抑郁症患者随机分为实验组和对照组,分别用米那普仑、艾司西酞普兰治疗8周,汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、副反应量表(TESS)评价疗效及不良反应。结果实验组与对照组疗效、不良反应差异无统计学意义(P>0.05),但实验组治疗1周、2周后HAMD评分低于同期对照组(P<0.05)。结论米那普仑与艾司西酞普兰治疗初发抑郁症患者均有较好效果,但米那普仑者起效较快。Objective To compare the clinical efficacy and adverse reactions of milnacipran versus escitalopram in primary depression. Methods Sixty-four patients with primary depression were randomly treated with milnacipran (experiment group) or escitalopram (control group) for 8 weeks. Clinical efficacy and adverse reactions were respectively evaluated by Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA) and Treatment Emergent Symptom Scale (TESS). Results Clinical efficacy and adverse reactions were comparable between 2 groups (P>0.05). HAMA scores were lower in experiment group than that in control group (P<0.05) 1-2 weeks after therapy. Conclusion Both milnacipran and escitalopram are effective in patients with primary depression except for rapid response of milnacipran.

关 键 词：米那普仑 艾司西酞普兰 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]