肝癌超声造影表现与微血管侵犯的相关性分析  

Correlation between the contrast-enhanced ultrasonography of hepatocellular carcinoma and microvascular invasion

作　　者：赵盛发[1] 刘连凤[1] 陈苗[1] 王夺 刘军杰[1] 赵媛 丁战玲[1] Zhao Shengfa;Liu Lianfeng;Chen Miao;Wang Duo;Liu Junjie;Zhao Yuan;Ding Zhanling(Department of Ultrasound,The Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学附属肿瘤医院超声科

出　　处：《广西医科大学学报》2019年第6期886-889,共4页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.81701721);广西壮族自治区中青年教师基础能力提升课题资助项目(No.GXMUYSF);广西医科大学青年科学基金资助项目(No.GXMUYSF201627);广西医疗卫生适宜技术开发与推广应用课题资助项目(No.S201632)

摘　　要：目的:分析肝癌超声造影(CEUS)表现与其分化程度及微血管侵犯(MVI)的相关性。方法:回顾性分析2015年3月至2018年3月广西医科大学附属肿瘤医院收治的73例肝癌患者的CEUS表现,依据术后病理检查结果,评估肝癌的分化程度及微血管侵犯(MVI)情况。结果:73例肝癌患者中,MVI阴性47例,阳性26例;低分化21例,中分化17例,高分化35例。MVI阳性组与MVI阴性组分化程度比较,差异有统计学意义(χ^2=36.632,P<0.001)。Spearman相关分析显示,肝癌MVI与分化程度呈负相关关系(r=-0.694,P<0.001)。MVI阳性组和MVI阴性组CEUS动脉期增强模式比较,差异无统计学意义(P>0.05),门脉期和延迟期增强模式比较,差异均有统计学意义(均P<0.05)。MVI阳性组和MVI阴性组始增时间、达峰时间比较,差异均无统计学意义(均P>0.05);而MVI阳性组廓清时间短于MVI阴性组(P<0.05)。结论:肝癌MVI有着特征性的CEUS表现,CEUS对肝癌MVI有重要的参考价值。Objective: To analyze the correlation between the contrast-enhanced ultrasonography (CEUS) ofhepatocellular carcinoma and its differentiation and microvascular invasion (MVI). Methods: A retrospective analysis of 73 patients with HCC in our hospital from March 2015 to March 2018 was performed.The tumor differentiation and MVI were evaluated by postoperative pathological examination. Results: MVI was present in 26 cases.HCC was characterized as poorly differentiated in 21 cases,moderately differentiated in 17 cases,and well differentiated in 35 cases.MVI was negatively correlated with the degree of differentiation of HCC (r=-0.694, P <0.001).No significant difference was found in contrast-enhanced mode during arterial phase between the MVI positive and MVI negative groups ( P >0.05),but there were significant differences in contrast-enhanced mode during portal phase and delayed phase between the two groups ( P <0.05).There was no significant difference in the initial time and peak time of contrast-enhanced MVI between the two groups ( P >0.05).The clearance time of MVI positive group was shorter than that of MVI negative group ( P <0.05). Conclusion: MVI of HCC has characteristic CEUS manifestations.CEUSwas valuable for predicting MVI of HCC.

关 键 词：超声造影 肝癌 微血管侵犯 

分 类 号：R735.7[医药卫生—肿瘤]