精神分裂症执行功能与血清炎性因子水平相关性研究  

The Correlation Between the Executive Function of Schizophrenia and the Level of Serum Inflammatory Factors

作　　者：陈祖金[1] 袁洪彬[1] 刘勇军 徐建坤 李坤 CHEN Zujin;YUAN Hongbin;LIU Yongjun(Min Kang Hospital of Suining City,Suining 629000,China)

机构地区：[1]遂宁市民康医院

出　　处：《中外医学研究》2019年第18期14-16,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨精神分裂症执行功能与血清炎性因子水平相关性。方法:选取61例精神分裂症患者(观察组)与60例健康志愿者(对照组),检测血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)和超敏C反应蛋白(hs-CRP),并采用威斯康星卡片分类测验(WCST)评估。结果:观察组血清白细胞介素-6、肿瘤坏死因子-α、白细胞介素-1分别为(22.19±4.29)、(33.27±10.03)、(24.80±9.78)ng/L,均明显高于对照组(P<0.05),而超敏C反应蛋白为(0.86±0.11)mg/L,明显低于对照组(P<0.05);观察组不同性别、年龄及病程患者IL-6、TNF-α、IL-1和hs-CRP比较差异无统计学意义(P>0.05);观察组白细胞介素-6、肿瘤坏死因子-α、白细胞介素-1与WCST评分呈负相关(P<0.05),超敏C反应蛋白与WCST评分无相关性(P>0.05)。结论:精神分裂症患者血清炎性因子水平与执行功能有一定相关性,值得进一步研究。Objective:To explore the correlation between the executive function of schizophrenia and the level of serum inflammatory factors. Method:Sixty-one patients with schizophrenia(observation group) and sixty healthy volunteers(control group) were selected for serum interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-aggressive),interleukin-1(IL-1) and hypersensitive C-reactive protein(hs-CRP).Wisconsin card classification test(WCST) was used for evaluation and comparison.Result:Serum interleukin-6,tumor necrosis factor-alpha and interleukin-1 of the observation group were (22.19±4.29)ng/L,(33.27±10.03)ng/L and (24.80±9.78)ng/L respectively,significantly higher than those of the control group(P<0.05),while hypersensitive C-reactive protein (0.86±0.11)mg/L was significantly lower than that of the control group(P<0.05).There were no statistically significant differences in IL-6,TNF-α,IL-1 and hs-CRP in the observation group patients of different gender,age and course(P>0.05).Interleukin-6,tumor necrosis factor-negative and interleukin-1 were negatively correlated with WCST score in the observation group(P<0.05),while hypersensitive C-reactive protein was not correlated with WCST score(P>0.05). Conclusion:The level of serum inflammatory factors in patients with schizophrenia is correlated with executive function,which is worth further study.

关 键 词：精神分裂症 炎性因子 执行功能 相关性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]