Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis  

作　　者：Zhiqiang Wu Linjun Weng Tengbo Zhang Hongling Tian Lan Fang Hongqi Teng Wen Zhang Jing Gao Yun Hao Yaxu Li Hu Zhou Ping Wang 

机构地区：[1]Tongji University Cancer Center, Shanghai Tenth People’s Hospital of Tongji University, School of Medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China [2]Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese, Academy of Sciences, Shanghai 201203, China

出　　处：《Cell Research》2019年第6期502-505,共4页细胞研究（英文版）

基　　金：the National Natural Science Foundation of China (81625019, 31830053, 31871398, 31801177, 31500735, 31801178, 31800757);the Science Technology Commission of Shanghai Municipality (16JC1404500, 18410722000);the Commission of Health and Family Planning of Shanghai Municipality (2017BR014 to P.W.;2017YQ068 to L.F.);the Young Elite Scientist Sponsorship Program by CAST(YESS)(2018QNRC001);the Shanghai Sailing Program (18YF1419500,18YF1419300);the Fundamental Research Funds For the Central Universities (22120170259, 22120180043, 22120180045, 22120180049).

摘　　要：Dear Editor,Cancer cells often upregulate the expression of ligands for the inhibitory immune checkpoints receptor to escape anti-tumor immunity1. Targeting inhibitory immune checkpoints has become one of the most promising anticancer therapeutic inventions. Infiltration of myeloid cells, especially phagocytic cells, to tumors is often associated with chemotherapy resistance and progression of various cancer types. Phagocytosis of cancer cells is the major mechanism for these myeloid cells-mediated antitumor activity. However, many types of cancer cells express high level of ‘don’t eat me’ signals on the cell surface to escape the phagocytic cells-mediated antitumor immunity.

关 键 词：AXIS expression SIRP ESCAPE Editor most has EAT 

分 类 号：TP393.09[自动化与计算机技术—计算机应用技术]