AXIS

作品数：1119被引量：2827H指数：22
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NLRP3 inflammasome and gut microbiota–brain axis:A new perspective on white matter injury after intracerebral hemorrhage
《Neural Regeneration Research》2026年第1期62-80,共19页Xiaoxi Cai Xinhong Cai Quanhua Xie Xueqi Xiao Tong Li Tian Zhou Haitao Sun 
supported by the Guangdong Basic and Applied Basic Research Foundation,No.2023A1515030045(to HS);Presidential Foundation of Zhujiang Hospital of Southern Medical University,No.yzjj2022ms4(to HS)。
Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have rev...
关键词：gut microbiota gut microbiota–brain axis immune intracerebral hemorrhage NEUROINFLAMMATION NLRP3 protein stroke THERAPEUTICS white matter injury 
Gut–brain axis and environmental factors in Parkinson's disease:bidirectional link between disease onset and progression
《Neural Regeneration Research》2025年第12期3416-3429,共14页Soo Jung Park Kyung Won Kim Eun Jeong Lee 
supported by the National Research Foundation(NRF)of Korea(2022R1C1C1005741 and RS-2023-00217595)。
Parkinson's disease has long been considered a disorder that primarily affects the brain,as it is defined by the dopaminergic neurodegeneration in the substantia nigra and the brain accumulation of Lewy bodies contain...
关键词：gut inflammation gut microbiome gut-brain axis micro/nano-plastics Parkinson’s disease Α-SYNUCLEIN 
Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease
《Neural Regeneration Research》2025年第10期2982-2997,共16页Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min Yi Weijun Peng 
financially supported by the National Natural Science Foundation of China,No.823 74552 (to WP);the Science and Technology Innovation Program of Hunan Province,No.2022RC1220 (to WP);the Natural Science Foundation of Hunan Province of China,Nos.2020JJ4803 (to WP),2022JJ40723 (to MY);the Scientific Research Launch Project for New Employees of the Second Xiangya Hospital of Central South University (to MY)
Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota.The aim of this study was to investigate systemic changes that occur in Alzhei...
关键词：Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis 
The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration
《Neural Regeneration Research》2025年第10期2741-2757,共17页Qianzi Jin Suyu Wang Yujia Yao Qin Jiang Keran Li 
supported by the National Natural Science Foundation of China,No.82171080;Nanjing Medical Science and Technology Development Project,No.YKK23264;Postgraduate Research&Practice Innovation Program of Jiangsu Province,Nos.JX10414151,JX10414152(all to KL)。
Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision.Unfortunately,the specific pathogenesis remains unclear,and effective early treatment options are...
关键词：age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora METABOLITE MICROECOLOGY neurodegenerative disease 
Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury被引量：1
《Neural Regeneration Research》2025年第8期2153-2168,共16页Xinyu You Lin Niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang 
supported by the National Natural Science Foundation of China,No.82174112(to PZ);Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine,No.22HHZYSS00015(to PZ);State-Sponsored Postdoctoral Researcher Program,No.GZC20231925(to LN)。
Traumatic brain injury is a prevalent disorder of the central nervous system.In addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for pati...
关键词：traumatic brain injury brain-gut-microbiome axis gut microbiota NEUROIMMUNE immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry 
Prophylactic effects of edible Lilium-egg yolk compound powder on depression-like behaviors in rats exposed to chronic unpredictable mild stress:a role of gut-brain axis
《Food Science and Human Wellness》2025年第3期1169-1184,共16页Yu Huang Yuxin Luo Sainan Tian Mengzhou Xie Liang Li Mingxing Jiang Zhiying Yuan 
financial support of the Natural Science Foundation of Hunan Province(2023JJ60481);the Natural Science Foundation of Changsha Municipality(kq2208181);the Hunan Provincial Department of Education’s Outstanding Youth Science Research Project(22B0360);the Hunan Provincial Department of Education’s Science Research Project(22C0191);the National Ministry of Agriculture’s Edible Lily Longshan Comprehensive Experimental Station Project(CARS-21);the Hunan University of Chinese Medicine Graduate Innovation Project(2023CX157)。
The incidence rate and harmfulness of depression are increasing yearly,and the research on the antidepressant effect of regulating the intestinal microecology balance has attracted widespread attention.The purpose of ...
关键词：Depression “Microbiota-gut-brain”axis Intestinal mucosal GR/BDNF/NPY LILIUM Egg yolk 
Tremella polysaccharide mitigates high-fat diet-induced anxiety-like behavior through the microbiota-gut-brain axis
《Food Science and Human Wellness》2025年第3期1062-1079,共18页Haicui Wu Shuyu Chen Wenxiu Zhang Yuqing Lu Jiayi Zheng Jinhui Chang Jiachi Chiou 
supported by the Seed Fund of Research Institute of Future Food(1-CD54)。
High-fat diet(HFD)consumption induces gut microbiota dysbiosis and neuropsychiatric disorders,including anxiety.Previous research found that Tremella polysaccharide(TP)exhibited neuroprotective effects in vitro and in...
关键词：Tremella polysaccharide High-fat diet Anxiety-like behavior Microbiota-gut-brain axis 
Breaking the cycle:Psychological and social dimensions of pediatric functional gastrointestinal disorders
《World Journal of Clinical Pediatrics》2025年第2期137-175,共39页Mohammed Al-Beltagi Nermin K Saeed Adel S Bediwy Reem Elbeltagi 
BACKGROUND Functional gastrointestinal disorders(FGIDs)in children present with chronic symptoms like abdominal pain,diarrhea,and constipation without identifiable structural abnormalities.These disorders are closely ...
关键词：Functional gastrointestinal disorders Psychiatric comorbidities Gut-brain axis Pediatric mental health Psychosocial stress 
Nintedanib regulates miR-23b-3p/TGFBR2 axis and competitively binds to TGFBR2 protein, inhibiting EMT process in human pterygium cells
《International Journal of Ophthalmology(English edition)》2025年第5期779-791,共13页Ke-Ke Zhang Meng Li Yan-Hong Liao Xiao-Tian Liu Yong-Bo Bao Yan Gong 
Supported by the Ningbo Natural Science Foundation(No.2023J212);Zhejiang Medical and Health Technology Program(No.2023KY1141).
AIM:To investigate the effects of nintedanib on epithelial-mesenchymal transition(EMT)in cells derived from pterygium,aiming to explore its potential as a pharmacological intervention for pterygium treatment.METHODS:P...
关键词：PTERYGIUM epithelial-mesenchymal transition nintedanib molecular docking CO-IMMUNOPRECIPITATION 
The effects of 17β-trenbolone and bisphenol A on sexual behavior and social dominance via the hypothalamic-pituitary-gonadal axis in male mice
《Journal of Environmental Sciences》2025年第5期54-67,共14页Xiang Zuo Minghe Sun Huijuan Bai Shuhui Zhang Jialu Luan Qian Yu Zhenhua Fu Qili Zhao Mingzhu Sun Xin Zhao Xizeng Feng 
supported by the National Natural Science Foundation of China(Nos.62027812 and 62273186).
17β-Trenbolone(17-TB)is well documented as an environmental endocrine disruptor in aquatic biological studies,but its effects on mammals remain poorly understood.Furthermore,17-TB acts as a hormone with properties si...
关键词：17β-Trenbolone(17-TB) Bisphenol A(BPA) hypothalamic-pituitary-gonadal axis(HPG) Sex hormones Social dominance Sexual behavior 
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