Breaking the cycle:Psychological and social dimensions of pediatric functional gastrointestinal disorders  

作　　者：Mohammed Al-Beltagi Nermin K Saeed Adel S Bediwy Reem Elbeltagi 

机构地区：[1]Department of Paediatrics,Faculty of Medicine,Tanta University,Tanta 31511,Alghrabia,Egypt [2]Department of Pediatric,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Manama 26671,Bahrain [3]Medical Microbiology Section,Department of Pathology,Salmaniya Medical Complex,Governmental Hospitals,Manama 26671,Bahrain [4]Medical Microbiology Section,Department of Pathology,The Royal College of Surgeons in Ireland-Bahrain,Busaiteen 15503,Muharraq,Bahrain [5]Department of Pulmonology,Faculty of Medicine,Tanta University,Tanta 31527,Alghrabia,Egypt [6]Department of Pulmonology,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Manama 26671,Bahrain [7]Department of Medicine,Royal College of Surgeons in Ireland-Bahrain,Busaiteen 15503,Muharraq,Bahrain

出　　处：《World Journal of Clinical Pediatrics》2025年第2期137-175,共39页世界临床儿科杂志(英文)

摘　　要：BACKGROUND Functional gastrointestinal disorders(FGIDs)in children present with chronic symptoms like abdominal pain,diarrhea,and constipation without identifiable structural abnormalities.These disorders are closely linked to gut-brain axis dysfunction,altered gut microbiota,and psychosocial stress,leading to psychia-tric comorbidities such as anxiety,depression,and behavioral issues.Under-standing this bidirectional relationship is crucial for developing effective,holistic management strategies that address physical and mental health.AIM To examine the psychiatric impacts of FGIDs in children,focusing on anxiety and depression and their association with other neurodevelopmental disorders of childhood,such as attention-deficit/hyperactivity disorder,emphasizing the role of the gut-brain axis,emotional dysregulation,and psychosocial stress.Key mechanisms explored include neurotransmitter dysregulation,microbiota imbalance,central sensitization,heightening stress reactivity,emotional dysregulation,and symptom perception.The review also evaluates the role of family dynamics and coping strategies in exacerbating FGID symptoms and contributing to psychiatric conditions.METHODS A narrative review was conducted using 328 studies sourced from PubMed,Scopus,and Google Scholar,covering research published over the past 20 years.Inclusion criteria focused on studies examining FGID diagnosis,gut-brain mechanisms,psychiatric comorbidities,and psychosocial factors in pediatric populations.FGIDs commonly affecting children,including functional constipation,abdominal pain,irritable bowel syndrome,gastroesophageal reflux,and cyclic vomiting syndrome,were analyzed concerning their psychological impacts.RESULTS The review highlights a strong connection between FGIDs and psychiatric symptoms,mediated by gut-brain axis dysfunction,dysregulated microbiota,and central sensitization.These physiological disruptions increase children’s vulnerability to anxiety and depression,while psychosocial factors-such as chronic stress,early-life t

关 键 词：Functional gastrointestinal disorders Psychiatric comorbidities Gut-brain axis Pediatric mental health Psychosocial stress 

分 类 号：R57[医药卫生—消化系统]