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作 者:汤翠青 王育红 崔桂梅[2] 张瑞岭[2] ang Cuiqing;Wang Yuhong;Cui Guimei;Zhang Ruiling(Mental Health Center of Qingyuan, The Third People' Hospital of Qingyuan, Qingyuan 511515, China;The Second Affiliated Hospital, Xinxiang Medical College, Xinxiang 453002, China)
机构地区:[1]清远市第三人民医院,清远市精神卫生中心,广东清远511515 [2]新乡医学院第二附属医院,河南新乡453002
出 处:《四川精神卫生》2019年第3期232-237,共6页Sichuan Mental Health
基 金:国家科技支撑计划项目(2008BAI49B02);广东省医学科研基金(A2014835);清远市科技计划项目(2014B010,2014B029)
摘 要:目的 探讨济泰片治疗轻度海洛因依赖者稽延性戒断症状的有效性和安全性,为降低轻度海洛因依赖者的复吸率提供参考。方法 在河南省新乡市第一强制隔离戒毒所选取符合《精神障碍诊断与统计手册(第4版)》(DSM-IV)诊断标准的轻度海洛因依赖者81例,采用随机数字表法分为济泰片组( n =40)和对照组( n =41)。济泰片组接受济泰片治疗,对照组给予济泰模拟片,两组均治疗24周。采用海洛因依赖稽延性戒断症状评定量表(RSPWSHA)评定疗效,采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表17项版(HAMD-17)及海洛因渴求问卷(HCQ)评定焦虑、抑郁症状和心理渴求程度,治疗期间监测药物不良反应、生命体征和实验室检查指标评估安全性。结果 济泰片组和对照组RSPWSHA、HAMA、HAMD-17 及HCQ总评分随治疗时间延长而降低( P <0.05),RSPWSHA总评分减分率随治疗时间延长而增加( P <0.05)。治疗8周后两组HCQ评分和治疗24周后两组HAMD-17总评分比较差异有统计学意义( P <0.05),其他各治疗时点两组各量表评分比较差异均无统计学意义( P 均>0.05)。结论 济泰片治疗轻度海洛因依赖者稽延性戒断症状可能疗效不明确。Objective To investigate the efficacy and safety of Jitai tabelets in the treatment of protracted withdrawal symptoms and to provide references for reducing relapse rate in mild heroin addicts. Methods From July 2011 to February 2012, a total of 81 mild heroin addicts who met the criteria of Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) were selected from the first compulsory and isolation drug rehabilitation center in Xinxiang, He'nan. The random number table method was used to divide the patients into the Jitai tabelets group ( n =40) and the control group ( n =41). Both two groups received medicine for 24 weeks. Rating Scale for Protracted Withdrawal Symptoms of Heroin Addicts (RSPWSHA) was used to measure the efficacy . Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale-17 item (HAMD-17) and Heroin Craving Questionnaire (HCQ) were used to assess anxiety, depression symptoms and heroin craving symptoms. During the treatment, adverse drug reactions, vital signs and laboratory examination indexes were monitored to evaluate the safety. Results In the two groups, the total scores of RSPWSHA, HAMA, HAMD-17 and HCQ decreased with the time of treatment ( P <0.05), and the reduction rate of RSPWSHA score increased along with treatment ( P <0.05). The HCQ score of the two groups after 8 weeks of treatment and the HAMD-17 score of the two groups after 24 weeks of treatment were significantly different from before the treatment ( P <0.05). There was no significant difference in scale scores between the two groups at other treatment time points ( P >0.05). Conclusion Jitai tabelets may not be effective in the treatment of protracted withdrawal symptoms for mild heroin addicts.
分 类 号:R749[医药卫生—神经病学与精神病学]
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