雷公藤临床应用的古今沿革  

Ancient and modern evolution on clinical application of Tripterygium wilfordii

作　　者：田振 张碧华[1] 杨莉萍[1] TIAN Zhen;ZHANG Bi-hua;YANG Li-ping(Department of Pharmacy,Beijing Hospital,National Center of Gerontology,Assessment of Clinical Drugs Risk and Individual Application Key Laboratory,Beijing 100730,China;Department of Pharmacy,Tai′an Traditional Chinese Medicion Hospital,Shandong Tai′an 271000,China)

机构地区：[1]北京医院药学部国家老年医学中心药物临床风险与个体化应用评价北京市重点实验室,北京100730 [2]泰安市中医医院药剂科,山东泰安271000

出　　处：《临床药物治疗杂志》2019年第5期19-23,共5页Clinical Medication Journal

摘　　要：查阅古代典籍及现代文献资料,对雷公藤的古今临床应用情况进行分析。明清时期就有关于雷公藤应用的记载,近现代有着持续的临床应用和发展。尤其是抗炎和免疫抑制作用机制的发现,推动了雷公藤在临床的广泛应用。通过查阅各省的中药材标准,发现雷公藤的用药部位和用法用量仍存在争议,给临床使用带来安全隐患。因此有必要阐明雷公藤毒性作用机制,制订统一标准,以保证雷公藤的安全合理使用。To analyze the clinical application of Tripterygium wilfordii by referring to the ancient books and the modern literature.There had been records on the application of Tripterygium wilfordii in Ming and Qing Dynasty,and fortunately,they were carried on and further developed modern times.The discovery of anti-inflammatory and immunosuppression mechanisms had promoted the application of Tripterygium wilfordii widely.However,there was still controversy about the medicinal part,usage and dosage of Tripterygium wilfordii,according to the standards of Chinese medicinal materials in various provinces,which brings safety risks to clinical application.It is needed to clarify the mechanism of Tripterygium wilfordii toxicity,so as to develop uniform standards to ensure the safety and reasonable application of Tripterygium wilfordii.

关 键 词：雷公藤 临床应用 古今沿革 抗炎 免疫抑制 用药部位 用法用量 

分 类 号：R741[医药卫生—神经病学与精神病学]