普罗布考片联合阿托伐他汀钙片与单用阿托伐他汀钙片治疗大动脉粥样硬化型脑梗死临床疗效的对比研究  

Comparative Study for Clinical Effect on Artery Atherosclerotic Cerebral Infarction between Probucol Tablets Combined with Atorvastatin Calcium Tablets and Atorvastatin Calcium Tablets Alone

作　　者：李霞[1] 周丽[2] 尹爱良[3] LI Xia;ZHOU Li;YIN Ai-liang(Department of Rehabilitation Medicine,Wendeng Central Hospital of Weihai,Weihai 264400,China)

机构地区：[1]山东省威海市文登中心医院康复医学科,264400 [2]山东省威海市文登中心医院神经内科,264400 [3]山东省威海市文登中心医院护理部,264400

出　　处：《实用心脑肺血管病杂志》2016年第12期66-69,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的比较普罗布考片联合阿托伐他汀钙片与单用阿托伐他汀钙片治疗大动脉粥样硬化型脑梗死患者的临床疗效。方法选取2012年1月—2015年5月威海市文登中心医院神经内科收治的大动脉粥样硬化型脑梗死患者110例,随机分为对照组与观察组,每组55例。在常规治疗基础上,对照组患者予以阿托伐他汀钙片治疗,观察组患者在对照组基础上加用普罗布考片治疗;两组患者均连续治疗6个月。比较两组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、颈动脉内中膜厚度(IMT)及斑块面积、血脂指标〔总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)〕、血清氧化低密度脂蛋白(ox-LDL)和基质金属蛋白酶9(MMP-9)水平、不良反应发生情况。结果治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗后观察组患者NIHSS评分低于对照组(P<0.05)。治疗前两组患者颈动脉IMT、斑块面积比较,差异无统计学意义(P>0.05);治疗后观察组患者颈动脉IMT、斑块面积小于对照组(P<0.05)。治疗前两组患者血清TC、TG、LDL-C、HDL-C水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清TC、TG、LDL-C水平低于对照组(P<0.05),而两组患者血清HDL-C水平比较,差异无统计学意义(P>0.05)。治疗前两组患者血清ox-LDL、MMP-9水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清ox-LDL、MMP-9水平低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论普罗布考片联合阿托伐他汀钙片治疗大动脉粥样硬化型脑梗死的临床疗效优于单用阿托伐他汀钙片,可更有效地改善患者神经功能,缩小动脉粥样硬化斑块,调节血脂代谢及降低血清ox-LDL、MMP-9水平,且安全性较高。Objective To compare the clinical effect on artery atherosclerotic cerebral infarction between probucol tablets combined with atorvastatin calcium tablets and atorvastatin calcium tablets alone. Methods From January 2012 to May2015,a total of 110 patients with artery atherosclerotic cerebral infarction were selected in the Department of Neurology,Wendeng Central Hospital of Weihai,and they were randomly divided into control group and observation group, each of 55 cases. Based on conventional treatment,patients of control group received atorvastatin calcium tablets alone,while patients of observation group received probucol tablets combined with atorvastatin calcium tablets;both groups continuously treated for 6months. NIHSS score,carotid intima-media thickness( CIMT), plaque area, blood liquids index( including TC, TG,LDL-C and HDL-C),serum levels of ox-LDL and MMP-9 before and after treatment,and incidence of adverse reactions were compared between the two groups. Results No statistically significant differences of NIHSS score was found between the two groups before treatment( P > 0. 05),while NIHSS score of observation group was statistically significantly lower than that of control group after treatment( P < 0. 05). No statistically significant differences CIMT or plaque area was found between the two groups before treatment( P > 0. 05),while CIMT and plaque area of observation group were statistically significantly smaller than those of control group after treatment( P < 0. 05). No statistically significant differences of serum level of TC,TG,LDL-C or HDL-C was found between the two groups before treatment,nor was serum HDL-C level between the two groups after treatment( P > 0. 05),while serum levels of TC,TG and LDL-C of observation group were statistically significantly lower than those of control group after treatment( P < 0. 05). No statistically significant differences of serum level of ox-LDL or MMP-9 was found between the two groups before treatment( P > 0. 05), while serum levels of ox-LDL and MMP-9 o

关 键 词：卒中 动脉粥样硬化 普罗布考片 阿托伐他汀钙片 疗效比较研究 

分 类 号：R743[医药卫生—神经病学与精神病学] R543.5[医药卫生—临床医学]