反流性食管炎患者血清CGRP含量变化及其与胃肠激素、炎性指标的相关性  

Changes of Serum CGRP Level in Patients with Reflux Esophagitis and Its Correlation with Gastrointestinal Hormones and Inflammatory Markers

作　　者：苏卫仙 代金玉[1] 史增辉 SU Wei-xian;DAI Jin-yu;SHI Zeng-hui(Department of Gastroenterology,the People's Hospital of Langfang,Langfang,Hebei 065000,China)

机构地区：[1]廊坊市人民医院消化内科

出　　处：《临床误诊误治》2019年第7期48-52,共5页Clinical Misdiagnosis & Mistherapy

基　　金：河北省医学科学研究重点课题计划项目(20150923);廊坊市科技支撑计划项目(2016013175)

摘　　要：目的探讨反流性食管炎(reflux eohagiti, RE)患者血清降钙素基因相关肽(calcitonin gene related peptide, CGRP)含量变化,以及其与胃肠激素、炎性指标的相关性。方法选取2016年2月-2018年5月廊坊市人民医院收治的RE患者127例作为RE组,再根据Savary-Miller分期分为Ⅰ~Ⅱ期亚组79例、Ⅲ~Ⅳ期亚组48例;另选取同期在我院行常规胃肠镜检查的健康志愿者80例作为对照组。比较各组血清CGRP,胃肠激素[胃泌素(GAS)、胃动素(MTL)、血管活性肠肽(VIP)、生长抑素(SS)],炎性指标[白细胞介素(IL)4、IL-17、IL-23、干扰素γ(IFN-γ)]含量,进而分析RE组CGRP与胃肠激素及炎性指标的相关性。结果 RE组患者血清CGRP、VIP、SS及IL-4、IL-17、IL-23、IFN-γ含量高于对照组,GAS、MTL含量低于对照组,差异均有统计学意义( P <0.05)。Ⅰ~Ⅱ期亚组、Ⅲ~Ⅳ期亚组患者血清CGRP、VIP、SS及IL-4、IL-17、 IL-23 、IFN-γ含量均高于对照组,GAS、MTL含量低于对照组,且随着RE病情的加重血清上述指标含量变化加剧,差异均有统计学意义( P <0.05)。相关性分析发现,RE患者血清CGRP含量与GAS、MTL含量呈负相关,与VIP、SS及IL-4、IL-17、IL-23、IFN-γ含量呈正相关。结论 RE患者血清CGRP含量异常升高,且随着病情的加重其水平逐渐升高;RE患者CGRP含量与机体胃肠激素分泌紊乱程度、全身炎性反应程度直接相关,可作为反映RE病情的客观指标,对RE病情评估具有重要意义。Objective To investigate the changes of serum calcitonin gene related peptide (CGRP) levels in patients with reflux esophagitis (RE), and its correlation with gastrointestinal hormones and inflammatory markers. Methods A total of 127 RE patients admitted to Langfang People's Hospital from February 2016 to May 2018 were selected as RE group. According to Savary-Miller classification criteria, they were divided into stage I-II subgroup ( n =79) and stage III-IV subgroup ( n =48). In addition, 80 healthy volunteers who underwent routine gastrointestinal endoscopy in our hospital during the same period were selected as normal control group. The levels of serum CGRP, gastrointestinal hormones [gastrin (GAS), motilin (MTL), vasoactive intestinal peptide (VIP),and somatostatin (SS)], inflammatory indicators [interleukin-4 (IL-4), interleukin-17 (IL-17), interleukin-23 ( IL-23 ), and interferon-γ(IFN-γ)] were compared in each group, and the correlation between CGRP and gastrointestinal hormones and inflammatory indicators in RE group was analyzed. Results The serum levels of CGRP, VIP, SS, IL-4, IL-17, IL-23 and IFN-γ in RE group were higher than those in normal control group, while the levels of GAS and MTL in RE group were lower than those in normal control group ( P <0.05). The serum levels of CGRP, VIP, SS, IL-4, IL-17, IL-23 and IFN-γ in stage Ⅰ-Ⅱ and Ⅲ-Ⅳ subgroups were higher than those in the normal control group, while the levels of GAS and MTL were lower than those in the normal control group, and the changes of the above-Mentioned indexes in the serum were increased with the aggravation of RE ( P <0.05). The correlation analysis showed that the serum CGRP content in RE patients was negatively correlated with GAS and MTL, and positively correlated with VIP, SS and inflammatory indexes such as IL-4, IL-17, IL-23 and IFN-γ. Conclusion The level of serum CGRP in RE patients was increased abnormally and gradually with the aggravation of the disease. The level of CGRP in RE patients is directly related t

关 键 词：食管炎 消化性 降钙素基因相关肽 胃肠激素 

分 类 号：R571[医药卫生—消化系统]