FRD特殊染色技术与液基细胞学检查在宫颈癌前病变筛查中的应用对比  

Application comparison of FRD special staining technique and thin-prep cytology test in screening of cervical precancerous lesions

作　　者：刘露晖 李桂宝[2] 王栾玲 黄凤友 陈新妹[3] 赖珍苗 贺凌云[4] 胡红云 LIU Lu-hui;LI Gui-bao;WANG Luan-ling;HUANG Feng-you;CHEN Xin-mei;LAI Zhen-miao;HE Ling-yun;HU Hong-yun(Xincheng Clinic, People′s Hospital of Yingde City in Guangdong Province, Yingde,513000, China;Division of Science and Education, People′s Hospital of Yingde City in Guangdong Province, Yingde,513000, China;Department of Pathology, People′s Hospital of Yingde City in Guangdong Province, Yingde,513000, China;Department of Gynecology, People′s Hospital of Yingde City in Guangdong Province, Yingde,513000, China)

机构地区：[1]广东省英德市人民医院新城门诊部,广东英德513000 [2]广东省英德市人民医院科教科,广东英德513000 [3]广东省英德市人民医院病理科,广东英德513000 [4]广东省英德市人民医院妇科,广东英德513000

出　　处：《中国当代医药》2019年第18期31-34,共4页China Modern Medicine

基　　金：广东省清远市社会发展领域自筹经费科技计划项目(2015B097)

摘　　要：目的比较FRD和TCT检查在宫颈癌筛查中的应用价值。方法采取自身对照法,选取2015年4月~2018年1月我院妇科门诊的2500例患者,均行FRD和TCT检查,FRD或(和)TCT结果阳性,再行阴道镜检查并取宫颈组织活检,以活检结果为金标准,评价FRD和TCT筛查的阳性检出率及FRD和TCT的诊断价值。以灵敏度、特异性、误诊率、漏诊率、阳性预测率、阴性预测率为诊断价值指标。结果2500例患者中,FRD和TCT的阳性检出率分别为10.32%和9.96%,两者比较差异无统计学意义(P>0.05)。FRD和TCT的灵敏度、特异性、误诊率、漏诊率、阳性预测率及阴性预测比较,差异均无统计学意义(P>0.05)。结论FRD和TCT对宫颈癌前病变筛查均具检出效能,诊断价值相当。Objective To compare the application value of folate receptor-mediated detection (FRD) and thin-prep cytology test (TCT) in cervical cancer screening. Methods By self-control method, from April 2015 to January 2018, 2500 patients in the gynaecological clinic of our hospital performed with FRD and TCT examinations were selected. When the FRD or/and TCT outcomes were positive, the cervical biopsy under colposcope was performed. The biopsy result was set as the golden standard. The positive detection rate of FRD and TCT screening and the diagnostic values of FRD and TCT were evaluated, the parameters were sensitivity, specificity, misdiagnosis rate, missed diagnosis rate, positive predictive rate, and negative predictive rate. Results Among 2500 patients, the positive detection rates of FRD and TCT were 10.32% and 9.96%, respectively, there was no significant difference between the two groups (P>0.05). With regard to the sensitivity, specificity, misdiagnosis rate, missed diagnosis rate, positive predictive rate and negative predictive rate of the FRD and TCT, there were no significant differences between the two detection methods (P>0.05). Conclusion FRD and TCT both obtain the effects of screening for cervical precancerous lesions, and the diagnostic value is equivalent.

关 键 词：宫颈癌前病变 筛查 叶酸受体介导的宫颈特殊染色 液基薄层细胞学检测 

分 类 号：R737.33[医药卫生—肿瘤]