VEGF、VEGFR在NSCLC组织中的表达及临床意义  

Clinical significance of VEGF and VEGFR expression in non-small cell lung cancer tissues

作　　者：雷芸[1] 闫春良[1] 薛旗山[1] 赵秋红[1] LEI Yun;YAN Chunliang;XUE Qishan;ZHAO Qiuhong(Department of Respiratory Medicine,Beijing General Hospital of Astronautics,Beijing 100076,China)

机构地区：[1]北京航天总医院呼吸内科

出　　处：《癌症进展》2019年第13期1573-1575,共3页Oncology Progress

摘　　要：目的探讨血管内皮生长因子(VEGF)、血管内皮生长因子受体(VEGFR)在非小细胞肺癌(NSCLC)组织中的表达情况及其意义。方法选取90例NSCLC患者的NSCLC组织和对应癌旁组织,采用免疫组织化学法检测两种组织中VEGF、VEGFR的表达情况,并对VEGF、VEGFR表达与NSCLC患者临床特征的关系进行分析。结果NSCLC组织中VEGF、VEGFR的阳性表达率均明显高于癌旁组织(P﹤0.01);TNM分期为Ⅲ~Ⅳ期、有淋巴结转移、合并胸腔积液NSCLC患者NSCLC组织中VEGF、VEGFR的阳性表达率均分别高于TNM分期为Ⅰ~Ⅱ期、无淋巴结转移、未合并胸腔积液的患者(P﹤0.05)。结论VEGF、VEGFR在NSCLC组织中表达上调,并且与患者的TNM分期、淋巴结转移情况及合并胸腔积液情况关系密切。Objective To investigate the clinical significance of expression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor in non- small cell lung cancer (NSCLC) tissues. Method NSCLC tumor tissues and adjacent non-cancerous tissues were selected from 90 patients with NSCLC. The expression of VEGF and VEGFR in both tissues was detected by immunohistochemistry assay and the relation between the VEGF and VEGFR expression and the clinical characteristic of NSCLC patients was analyzed. Result The positive expression rate of VEGF and VEGFR in NSCLC tumor tissues were significantly higher than that in adjacent non-cancerous tissues (P< 0.01). The positive expression rate of VEGF and VEGFR in NSCLC tumor tissues from patients with TNM staging IIIIV, lymph node metastasis and pleural effusion were significantly higher than those from patients with TNM staging I-II, no lymph node metastasis and no pleural effusion (P<0.05). Conclusion The expression of VEGF and VEGFR is up-regulated in NSCLC tumor tissues and closely association with TNM classification, lymph node metastasis and pleural effusion.

关 键 词：血管内皮生长因子 非小细胞肺癌 胸腔积液 临床特征 

分 类 号：R734.2[医药卫生—肿瘤]