精神病临床高危人群及首发精神分裂症患者听觉事件相关电位P300的θ频谱改变  

Abnormality of θ oscillation in auditory event-related potential P300 in patients with clinical high risk of psychosis or first-episode schizophrenia

作　　者：郭茜[1] 王俊杰 刘旭 郑丽娜[4] 李冠军[1] 李金 王继军[5] GUO Qian;WANG Jun-jie;LIU Xu;ZHENG Li-na;LI Guan-jun;LI Jin;WANG Ji-jun(Department of Early Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;Suzhou Guangji Hospital,Jiangsu Province,Affiliated Guangji Hospital of Soochow University,Suzhou 215137,China;Institute of Neuroscience,Shanghai Institute for Biological Science,Chinese Academy of Science,Shanghai 200031,China;Department of Psychiatry and Psychology,Liaocheng People’s Hospital,Liaocheng 252000,China;Department of Electroencephalography and Imaging,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心早期精神病性障碍科,上海200030 [2]江苏省苏州市广济医院,苏州大学附属广济医院,苏州215137 [3]中国科学院神经科学研究所,上海200031 [4]山东省聊城市人民医院精神心理科,聊城252000 [5]上海交通大学医学院附属精神卫生中心脑电影像眼动研究室,上海200030

出　　处：《上海交通大学学报（医学版）》2019年第6期593-597,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81501152);国家科技部“十三五重大慢性非传染性疾病防控研究”重点专项(2016YFC1306800);上海市精神卫生中心“飞翔计划”人才项目(2018-FX-04);上海交通大学医学院“博士创新基金”项目(BXJ201743);上海市卫生和计划生育委员会科研课题计划(201540314)~~

摘　　要：目的·探索精神病临床高危(clinical high risk,CHR)人群和首发精神分裂症(first episode schizophrenia,FES)患者听觉事件相关电位P300的θ振荡改变,以及与临床症状之间的关系。方法·招募18 名精神病CHR患者(CHR组)、18名FES患者(FES组)以及19名健康对照(健康对照组),完成标准听觉Oddball实验范式,并用64导联脑电帽记录脑电活动。选择Fz、Cz、Pz电极进行P300波幅、峰潜伏期以及P300的θ振荡时-频分析。结果·3组被试的P300波幅间差异有统计学意义(P=0.004),其中FES组(P=0.001)及CHR组(P=0.026)的波幅均显著小于健康对照组,CHR组和FES组间差异无统计学意义(P>0.05)。θ引发能量值在3组间有显著差异(P=0.022),其中FES组显著低于健康对照组(P=0.008),CHR组边缘性低于健康对照组(P=0.054),CHR组与FES组间差异无统计学意义(P>0.05)。θ诱发能量值在3组间仅有边缘性差异(P=0.054)。相关性分析发现,FES组的阳性与阴性症状量表总分及部分分量表评分与Cz电极、Pz电极的P300波幅具有显著相关性(均P<0.05)。结论·CHR与FES患者的听觉P300波幅以及P300的θ振荡均存在异常,但CHR患者的改变较FES患者轻微,且其P300的θ振荡仅局限于引发能量受损,而诱发能量并未受损。Objective·To explore the relationship between θ oscillation of auditory event-related potential P300 and clinical symptoms in the patients with clinical high risk (CHR) of psychosis or first episode schizophrenia (FES).Methods·A total of 18 patients with CHR of psychosis (CHR group),18 patients with FES (FES group) and 19 healthy controls (control group) were recruited to complete the standard auditory Oddball paradigm as well as electroencephalogram (EEG) recording with 64-channel EEG cap.Fz,Cz and Pz electrodes were selected to compare the amplitudes and peak latent periods among the three groups,and time-frequency analysis of the θ oscillation in P300 was performed.Results·There was significant difference in the amplitudes of P300 among the three groups (P=0.004).The amplitudes of P300 in FES group (P=0.001) and CHR group (P=0.026) were both significantly lower than that of control group.There was no difference between CHR group and FES group in P300 amplitude (P>0.05).θ Oscillation induced power was significantly different among the three groups (P=0.022).The induced power value of FES group was significantly lower than that of control group (P=0.008);and it was marginally lower in CHR group as compared to that of control group (P=0.054).There was no difference between CHR group and FES group (P>0.05).There was trending difference in θ oscillation evoked power among the three groups (P=0.054).The correlation analysis showed that the total and subscale scores of Positive and Negative Syndrome Scale in FES group were significantly correlated with the amplitudes of P300 at Cz and Pz electrodes (P<0.05).Conclusion·There are significant abnormalities in the amplitude of auditory P300 and θ oscillation of P300 in both CHR and FES patients;however,the change in CHR patients is less severe than that of FES patients.The impaired θ oscillation of P300 in CHR patients is limited to induced power,but evoked power is not impaired.

关 键 词：精神病临床高危人群 首发精神分裂症 θ振荡 诱发能量 引发能量 

分 类 号：R749.3[医药卫生—神经病学与精神病学]