Gastric adenocarcinoma of fundic gland type after Helicobacter pylori eradication:A case report  

作　　者：Ya-Nan Yu Xiao-Yan Yin Qi Sun Hua Liu Qi Zhang Yun-Qing Chen Qing-Xi Zhao Zi-Bin Tian 

机构地区：[1]Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China [2]Department of Pathology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China [3]Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China

出　　处：《World Journal of Clinical Cases》2019年第13期1696-1702,共7页世界临床病例杂志

基　　金：Supported by the National Natural Science Foundation of China,No.81502025;China Postdoctoral Science Foundation,No.2018M632631

摘　　要：BACKGROUND Gastric adenocarcinoma of fundic gland type (GA-FG) has recently been proposed as a novel histological type of gastric cancer. CASE SUMMARY We report a case of GA-FG in a 77-year-old Chinese woman with epigastric distention who was referred to endoscopy for the management of an incidentally found submucosal tumor-like elevated lesion in the lower part of the gastric body. The tumor occurred after Helicobacter pylori (H. pylori) eradication therapy without long-term use of proton pump inhibitors. Complete and curable removal of the tumor was performed by endoscopic submucosal dissection. Histopathological findings showed numerous cells with basophilic cytoplasm and mildly atypical nuclei-like chief cells of the fundic gland. The tumor was observed to have the so-called “endless glands” pattern of the well-differentiated mixed phenotype. A safe resection margin without lymphatic and venous invasion was observed. As the tumor occurred after H. pylori eradication therapy, it is unknown whether there was a relationship with H. pylori eradication. The patient will be followed up by periodic gastroscopic observation. CONCLUSION In conclusion, we report a case of GA-FG after H. pylori eradication therapy without long-term proton pump inhibitors use. Further analysis of similar cases will reveal the clinical behavior of GA-FG.BACKGROUND Gastric adenocarcinoma of fundic gland type(GA-FG)has recently been proposed as a novel histological type of gastric cancer.CASE SUMMARY We report a case of GA-FG in a 77-year-old Chinese woman with epigastric distention who was referred to endoscopy for the management of an incidentally found submucosal tumor-like elevated lesion in the lower part of the gastric body.The tumor occurred after Helicobacter pylori(H.pylori)eradication therapy without long-term use of proton pump inhibitors.Complete and curable removal of the tumor was performed by endoscopic submucosal dissection.Histopathological findings showed numerous cells with basophilic cytoplasm and mildly atypical nuclei-like chief cells of the fundic gland.The tumor was observed to have the so-called "endless glands" pattern of the well-differentiated mixed phenotype.A safe resection margin without lymphatic and venous invasion was observed.As the tumor occurred after H.pylori eradication therapy,it is unknown whether there was a relationship with H.pylori eradication.The patient will be followed up by periodic gastroscopic observation.CONCL USION In conclusion,we report a case of GA-FG after H.pylori eradication therapy without long-term proton pump inhibitors use.Further analysis of similar cases will reveal the clinical behavior of GA-FG.

关 键 词：GASTRIC ADENOCARCINOMA Fundic GLAND HELICOBACTER PYLORI ERADICATION Case report 

分 类 号：R[医药卫生]