基于活性胰岛素累积量模糊自适应比例-积分-微分闭环胰岛素的控制方法  

A fuzzy adaptive proportional-integral-derivative(PID) control strategy based on insulin-on-board control method of closed-loop insulin infusion

作　　者：余丽玲[1] 张刚平[1] 刘文平 徐彬锋[1] 金浩宇[1] Yu Liling;Zhang Gangping;Liu Wenping;Xu Binfeng;Jin Haoyu(Guang Dong Food and Drug Vocational College,Guangzhou 510520,Guangdong Province,China)

机构地区：[1]广东食品药品职业学院

出　　处：《中国组织工程研究》2019年第30期4816-4821,共6页Chinese Journal of Tissue Engineering Research

基　　金：广东省科技计划项目(2015A020214016),项目负责人:金浩宇;广东省医学科学技术研究基金项目(B2017093),项目负责人:余丽玲;广东食品药品职业学院院级课题院级课题(2015YZ020,2018ZR032),项目负责人:余丽玲~~

摘　　要：背景:智能的血糖控制算法是闭环式人工胰腺的重要环节。目的:为了有效控制1型糖尿病患者的血糖浓度,降低患者高、低血糖事件的发生概率,提出基于活性胰岛素累积量模糊自适应比例微积分的闭环胰岛素控制算法。方法:根据实时监测的人体血糖数据,采用比例微积分算法模拟人体β细胞分泌胰岛素生理传输过程,然后不断优化比例-积分-微分控制器参数数值,利用活性胰岛素累积量进行修正模糊比例-积分-微分计算出来的胰岛素剂量,使得最终计算出适合该患者的最佳胰岛素泵给药量。结果与结论:该算法在美国弗吉尼亚大学与意大利帕多氏联合开发的UVa/Padova仿真平台进行了算法性能的测试,仿真实验结果表明该控制算法显著降低了低血糖事件,将血糖水平控制在设定的目标区间,提高了胰岛素注射疗法的精确性和有效性,显著降低了各种并发症的产生。BACKGROUND: Intelligent blood glucose control algorithm is an important part of closed loop artificial pancreas. OBJECTIVE: To effectively control the blood glucose level of patients with type 1 diabetes mellitus, reduce the incidence of high or low blood glucose level, and propose a closed-loop insulin control algorithm based on fuzzy adaptive proportional-integral-derivative control strategy. METHODS: According to the real-time monitoring data of continuous human blood glucose, proportional-integral-derivative algorithm was used to simulate the physiological transmission process of insulin secretion from human β cells. Then the parameters of the proportional-integral-derivative controller were continuously optimized. The amount of insulin-on-board was used to correct the insulin dose calculated by fuzzy adaptive proportional-integral-derivative algorithm to realize the optimal control of insulin pump. RESULTS AND CONCLUSION: The performance of the proposed control algorithm was tested using the UVa/Padova stimulator jointly developed by the University of Virginia (USA) and University of Padova (Italy). Results showed that the insulin control algorithm significantly reduced hypoglycemia events, controlled blood glucose levels in the designated target range, increased the accuracy and effectiveness of insulin injection therapy, and greatly reduced the occurrence of various complications.

关 键 词：1型糖尿病 人工胰腺 模糊自适应PID 血糖浓度 胰岛素 活性胰岛素累积量 连续血糖监测 仿真平台 

分 类 号：R459.9[医药卫生—治疗学] R311[医药卫生—临床医学]