UbcH10在肝癌组织中的表达及临床意义  

Expression and Clinical Significance of UbcH10 in Hepatocellular Carcinoma

作　　者：田明[1] 常伟平[1] 盛旭东[2] TIAN Ming;CHANG Wei-ping;SHENG Xu-dong(Department of General Surgery, the First Affiliated Hospital,Xi'an Medical College,Xi'an 710077,Shaanxi,China;Department of Neurosurgery,the First Affiliated Hospital,Xi'an Medical College,Xi'an 710077,Shaanxi,China)

机构地区：[1]西安医学院第一附属医院普外科,陕西西安710077 [2]西安医学院第一附属医院神经外科,陕西西安710077

出　　处：《医学信息》2019年第14期72-74,共3页Journal of Medical Information

基　　金：陕西省教育厅专项科研基金面上项目(编号:2013JK 0791)

摘　　要：目的探讨UbcH10在肝癌组织中的表达及临床意义。方法收集2018年2月~10月在本院就诊并行手术切除的肝癌患者肿瘤组织标本30例,并以相应癌旁正常组织(距离肿瘤组织>5cm)为参照。采用免疫组化分析肝癌组织和癌旁正常肝组织中的UbcH10蛋白的表达量以及肝癌UbcH10蛋白表达与临床病理特征的关系。结果有93.33%的肝癌组织中显示UbcH10表达,仅有6.67%的癌旁正常肝组织显示UbcH10表达,肝癌组织中UbcH10表达高于癌旁正常肝组织,差异有统计学意义(P<0.05);其中高分化肝癌组织UbcH10表达低于低分化肝癌组织,差异有统计学意义(P<0.05)。不同年龄、性别患者中UbcH10表达比较,差异无统计学意义(P>0.05);不同肿瘤大小、组织学分化程度、淋巴结是否转移患者中UbcH10表达比较,差异有统计学意义(P<0.05)。结论UbcH10在肝癌患者肝组织中过度表达,并与肿瘤大小、分化程度及淋巴结转移相关。UbcH10可作为肝癌患者肿瘤治疗的预后标志物和潜在分子靶点。Objective To investigate the expression and clinical significance of UbcH10 in hepatocellular carcinoma.Methods 30 cases of tumor tissue specimens from patients with liver cancer who underwent surgical resection in our hospital from February to October 2018 were collected and referenced to the corresponding adjacent normal tissues (>5 cm from tumor tissue).The expression of UbcH10 protein in liver cancer tissues and adjacent normal liver tissues and the relationship between UbcH10 protein expression and clinicopathological features were analyzed by immunohistochemistry.Results U3cH10 expression was observed in 93.33% of liver cancer tissues,and only 6.67% of adjacent normal liver tissues showed UbcH10 expression.The expression of UbcH10 in liver cancer tissues was higher than that in adjacent normal liver tissues,the difference was statistically significant (P<0.05).The expression of UbcH10 in highly differentiated liver cancer tissues was lower than that in poorly differentiated liver cancer tissues,the difference was statistically significant (P<0.05).There was no significant difference in the expression of UbcH10 between patients of different ages and genders (P>0.05).The expression of UbcH10 in patients with different tumor size,histological differentiation and lymph node metastasis was statistically significant (P<0.05).Conclusion UbcH10 is overexpressed in liver tissues of patients with liver cancer and is associated with tumor size,differentiation and lymph node metastasis.UbcH10 can be used as a prognostic marker and a potential molecular target for tumor therapy in patients with liver cancer.

关 键 词：UBCH10 肝癌组织 癌旁正常肝组织 

分 类 号：R735.7[医药卫生—肿瘤]